Research

UTMB develops an oral vaccine against Salmonella


Barrows1700
By Donna Ramirez | December 15, 2016

Researchers from The University of Texas Medical Branch at Galveston have developed a vaccine against salmonella poisoning designed to be taken by mouth. The findings are detailed in an article published in Frontiers in Cellular and Infection Microbiology.

In earlier studies, the UTMB researchers developed potential vaccines from three genetically mutated versions of the salmonella bacteria, that is Salmonella Typhimurium, that were shown to protect mice against a lethal dose of salmonella. In these studies, the vaccines were given as an injection.

However, oral vaccination is simplest and least invasive way to protect people against salmonella infection. Taking this vaccine by mouth also has the added advantage of using the same pathway that salmonella uses to wreak havoc on the digestive system.

“In the current study, we analyzed the immune responses of mice that received the vaccination by mouth as well as how they responded to a lethal dose of salmonella, said Ashok Chopra, UTMB professor of microbiology and immunology. “We found that the orally administered vaccines produced strong immunity against salmonella, showing their potential for future use in people.”

There is no vaccine currently available for salmonella poisoning. Antibiotics are the first choice in treating salmonella infections, but the fact that some strains of salmonella are quickly developing antibiotic resistance is a serious concern. Another dangerous aspect of salmonella is that it can be used as a bioweapon – this happened in Oregon when a religious cult intentionally contaminated restaurant salad bars and sickened 1,000 people.

Salmonella is responsible for one of the most common food-borne illnesses in the world. In the US alone, the Centers for Disease Control and Prevention estimates that there are about 1.4 million cases with 15,000 hospitalizations and 400 deaths each year. It is thought that for every reported case, there are approximately 39 undiagnosed infections. Overall, the number of salmonella cases in the US has not changed since 1996.

Salmonella infection in people with compromised immune systems and children under the age of three are at increased risk of invasive non-typhoidal salmonellosis, which causes systemic infection. There are about one million cases globally per year, with a 25 percent fatality rate.

Other authors include UTMB’s Tatiana Erova, Michelle Kirtley, Eric Fitts, Duraisamy Ponnusamy, Jourdan Andersson, Yingzi Cong, Bethany Tiner and Jian Sha as well as Wallace Baze from the University of Texas M.D. Anderson Cancer Center. The study was supported by UTMB and The National Institutes of Health.

Tags | Research



Social Posts

profile_image

BCMHouston

@bcmhouston

RT @BCMEthics: Alternative science: The importance of informed policymaking https://t.co/O3lLsZAsr3 via @bcmhouston

18 mins ago
profile_image

Rice University

@RiceUniversity

Here?s a tip: Indented cement shows unique properties. https://t.co/GuxKPV2NgV https://t.co/XBSiKhJ5IG

22 mins ago
profile_image

BCMHouston

@bcmhouston

Congratulations to Drs. Jonathan Davies, James Orengo and Geoffrey Preidis, recipients of the 2017 Chao Physician-S? https://t.co/8OZYgv4laf

22 mins ago
profile_image

BCMHouston

@bcmhouston

@BCMEthics' Cody Brannan says peer-reviewed data should be considered for science-based policymaking. https://t.co/nkLOkMfQ7h

22 mins ago
profile_image

Baylor College of Medicine

BaylorCollegeOfMedicine

Baylor College of Medicine Center for Medical Ethics and Health Policy's Cody Brannan says peer-reviewed data and scientific consensus should be considered fo...

22 mins ago
profile_image

MD Anderson

@MDAndersonNews

@RandyPro Congratulations, Randy! Best wishes to you.

32 mins ago
profile_image

CHI St Luke's Health

@CHI_StLukes

RT @CHI_Updates: Even hours after a near-drowning incident, mild symptoms can cause serious complications - learn more with this info from?

42 mins ago
profile_image

MD Anderson

@MDAndersonNews

Tips for enjoying a healthy #barbecue: https://t.co/p4NKLod53I @FocusedonHealth #endcancer https://t.co/iaP5EstrZP

49 mins ago
profile_image

UTHealth

@UTHealth

RT @UTSDhouston: I scream! You scream! We all scream for ice cream! Dean Valenza's 9th Annual Scream Out ice? https://t.co/kzog82SPID

1 hour ago
profile_image

Texas Children's

@TexasChildrens

"This doctor, who I didn't know at the time, was going to change our lives." Read full story: https://t.co/3Kn1q4rap6 #texaschildrens

1 hour ago
profile_image

Veterans Affairs

@DeptVetAffairs

Magic Valley groups ride to honor Vietnam Veterans https://t.co/Bc1PCvQYfH via @emilydukeKMVT

1 hour ago
profile_image

Rice University

@RiceUniversity

Communities of cells communicate to coordinate their actions, but how do they coordinate with other communities?? https://t.co/TynLuAsTS6

1 hour ago
profile_image

UTHealth

@UTHealth

#Trampolines are responsible for thousands of annual ER visits. Dr. Sasha Adams shared safety tips w/ @Fox26Houston: https://t.co/4sbo09Lc1j

1 hour ago
profile_image

UTHealth

@UTHealth

After 3-year-old Ishaan fell into a pool and nearly drowned, he was fortunate to be in the care of Dr. Soham Roy: https://t.co/rCkS06zkUs

1 hour ago
profile_image

MD Anderson Cancer Center

MDAnderson

“I wasn’t going to give up. If there’s any chance, I’m going to take it,” Maria Newhouse recalls telling herself when she was diagnosed with breast cancer. Lea...

1 hour ago