{"id":8956,"date":"2017-03-01T16:06:36","date_gmt":"2017-03-01T16:06:36","guid":{"rendered":"https:\/\/www.tmc.edu\/news\/tmc-spotlight-mauro-ferrari-ph-d\/"},"modified":"2019-08-16T15:02:57","modified_gmt":"2019-08-16T15:02:57","slug":"tmc-spotlight-mauro-ferrari-ph-d","status":"publish","type":"post","link":"https:\/\/www.tmc.edu\/news\/2017\/03\/tmc-spotlight-mauro-ferrari-ph-d\/","title":{"rendered":"TMC Spotlight: Mauro Ferrari, Ph.D."},"content":{"rendered":"

MAURO FERRARI, PH.D.<\/strong>, president and CEO of Houston Methodist Research Institute, is known for his revolutionary treatment of cancer using nanotechnology. Ferrari spoke with Pulse about \u2018disciplinary fracking,\u2019 what soothes his soul, and why he identifies with the butler from Downton Abbey.<\/em><\/p>\n

Q | You\u2019re an avid marathon runner, which requires a lot of mental and physical discipline. How does that discipline translate to your research?<\/strong><\/p>\n

A | Running is a metaphor for cancer research in the sense that rule No. 1 is you don\u2019t stop. No matter what happens, you keep on going. That\u2019s what it takes. Now, to bring true innovation to the clinic, it\u2019s a journey of many, many years. Incremental innovation can go a little bit faster, but, of course, incremental innovation hasn\u2019t cured metastatic disease yet. To cure metastatic disease, you need to be able to think of things that are truly different\u2014starting from scratch\u2014and refuse to die and keep on going.<\/p>\n

Cancer research is also kind of like a game of basketball, with a few differences. One, you are pretty much 30 points behind the whole time, which doesn\u2019t mean you can\u2019t win the game, but it means that if you don\u2019t have the psychological mindframe that you\u2019re not going to stop playing no matter what, then you know you\u2019re never going to win. You can win, but not if you quit.<\/p>\n

Second difference is a basketball game is 48 minutes. Each of the games I\u2019m talking about is at least 20 years. Third big difference is you only get one game per life, so you have to use it wisely. That\u2019s the way I think: Play the best you can and try to make good things happen.<\/p>\n

Q | How many marathons have you run?<\/strong><\/p>\n

A | About 30, but I take my time. One reason why I think I like it so much is it\u2019s easier than any day in the office. Also, I\u2019m not very good at it. That\u2019s the important part. I think it teaches you humility.<\/p>\n

I like to run what they call \u2018ultra-marathons\u2019 up mountains. I\u2019ve done marathons with a total elevation\u00a0gain of 12,000 feet. It\u2019s a mystical experience. The longest one I\u2019ve done, the 100K (62 miles), took me about 16.5 hours.<\/p>\n

Everybody is able to celebrate when they win. If it comes easy, boom, you do it again and you do it again. Learning comes from slogging through things you are having a hard time doing. I think that\u2019s a good lesson.<\/p>\n

Q | I understand your first wife, Marialuisa, passed away from cancer while you were a professor at the University of California, Berkeley. How did that personal tragedy shape your life and career?<\/strong><\/p>\n

A | To me, it\u2019s a notion of philosophy of life, if you will. I don\u2019t know what the meaning of life is. I don\u2019t think anyone does. But I have this sneaky suspicion that it\u2019s got something to do with turning one\u2019s own pain and suffering into good things for others. If you\u2019re able to do that, the meaning of life is within reach. That is kind of my notion that brings joy, that brings a sense of mission, that brings some settlement for all the restlessness of life. If you turn your own pain into good things for others, I think that\u2019s a step in the right direction.<\/p>\n

Q | How did you meet your wife Paola?<\/strong><\/p>\n

A | I knew Paola even before I knew Marialuisa. We are from the same small part of the same small town up in the mountains of Italy. We went to the same high school, though she\u2019s a few years younger than I am. She had come to the U.S. independently to be a Fulbright Scholar at Columbia University, working at the United Nations.<\/p>\n

The two of us\u2014the three of us, including Marialuisa\u2014come from very humble backgrounds. Nobody in our three families had ever been to college, so this was a major step in breaking away from tradition.<\/p>\n

Q | How so?<\/strong><\/p>\n

A | We have steel mills in our town, and that was a traditional place of occupation for everybody. It was\u00a0either that or the military. My family was military. I was the black sheep of the family; I went to\u00a0college. I was really focused and got my Ph.D. from Berkeley. I get back to Italy and I\u2019m thinking, \u2018Man, I\u2019ve gotten my break into big-time action!\u2019 All those Nobel laureates at Berkeley. Back in my day, there were 17 Nobel laureates. I was watching all these great people and I was thinking great thoughts.<\/p>\n

Before I married Marialuisa, I actually stopped going to college for six months so that I could make
\nmoney any which way I could, including tutoring high school kids. I was a tutoring machine. When I got back to Italy after Berkeley, my father said, \u2018Well, now you\u2019ve got your Ph.D., you can charge more when you tutor high school kids!\u2019 You see the disconnect? It was all in good faith, but what the heck did they know about Cal Berkeley, universities, Nobel laureates and all that stuff? It\u2019s entirely different.<\/p>\n

Q | You started as a mathematical physicist and mechanical engineer, then moved into medicine. Tell me about that combination of disciplines.<\/strong><\/p>\n

A | At Berkeley, I was a mathematician who used to work on mathematical physics. My job was in the\u00a0mathematical foundation of the theory of relativity and how it applies to the expansion of the universe. Then I got a Ph.D. in mechanical engineering, then taught and got a tenured faculty position in materials science, civil engineering and bioengineering. That was just at Berkeley. Then I moved over to Ohio State, where I was a full tenured professor of medicine. I started medical school at age 43 as a full professor of medicine. That was a lot of fun.<\/p>\n

You know the words \u2018interdisciplinary\u2019 and \u2018multidisciplinary?\u2019 I don\u2019t like either word. I like the word \u2018superdisciplinary.\u2019 You know when you get excited and the sparks start flying when you put two different things together? Now that I\u2019ve moved to Texas, the way I think about what I try to do is \u2018disciplinary fracking.\u2019 I go deep, and I break barriers so the juices start flowing and everybody wins.<\/p>\n

You can get little earthquakes, but in this case, it\u2019s good earthquakes.<\/p>\n

Q | How will a \u2018super-disciplinary\u2019 approach or \u2018disciplinary fracking\u2019 help us cure cancer?<\/strong><\/p>\n

A | The reason we haven\u2019t been able to cure cancer is diversity. There is no such thing as one disease. There are hundreds of diseases. Every cancer is different, and you can only fight like with like. Unless you have a diversity of approaches that work together, you cannot beat the diversity of cancers. Nobody can do it solo.<\/p>\n

It\u2019s important that we have depth in all of the disciplines, but it is equally important\u2014perhaps even more important\u2014that we understand how to connect them in a synergistic fashion. I\u2019m a big believer in the notion that science is autobiography and that science is essentially self-confession. We can only do the science that our brain cells are wired to do.<\/p>\n

My brain sees patterns, sees connections. I\u2019ve been a professional mathematician, professional engineer, this and that. I wasn\u2019t good at any. I\u2019m a little bit better at putting things together and seeing ways in which things can get together and do things that are impressive, which is good for the job that I do.<\/p>\n

Everything we do here is at the service of patients. A lot of times in the sciences, we do science for the\u00a0sake of science. I don\u2019t mean to criticize because that\u2019s the right thing for a lot of people. That\u2019s right for universities, but here, we are a hospital.<\/p>\n

Every day, I get phone calls or emails or contacts from people who are desperate, who are dying. Someone with breast cancer, metastatic disease, their life expectancy on average 24 to 36 months. It\u2019s them, it\u2019s their husbands, their children who contact me and say, \u2018We read about this thing in mice. Can you do it to my loved one or to me?\u2019 Those are very difficult questions and we field each and every one of them personally.<\/p>\n

Q | You have a framed printout with the words \u2018Luke 12:48\u2019 above your office doorway. What does that mean to you?<\/strong><\/p>\n

A | This is the passage from the Gospel of Luke where it talks about the fact that from people to whom much is given, much is expected. Look where we are: the No. 1 medical center in the world. If we don\u2019t work on the big problems, who will? We can\u2019t run away, shy away. It\u2019s a responsibility. It\u2019s an ethical responsibility.<\/p>\n

Q | There\u2019s also a handwritten note next to it. What\u2019s the story behind that?<\/strong><\/p>\n

A | That\u2019s the story of a young lady who actually came in from Italy. She was 16, seeking desperate, experimental treatment. She was taken care by another institution and by great people who did all the right things, but she was a desperate case with cancer of the brain. As part of her treatment and the evolution of her disease, at a certain point, she went into a coma. I had become very close to her and her family. They were from Italy, so I was kind of their reference.<\/p>\n

Then in the summer, I was on a trip for a couple of weeks while she was in a coma. I came back and I wanted to see the family in the ICU. I thought there was a good likelihood that she would be dead, but she wasn\u2019t. Not only that, but she had woken up from the coma. She couldn\u2019t speak, but she could see.<\/p>\n

I bought a little plush toy for her at the airport on the way in. I didn\u2019t want to show up emptyhanded. She saw that, so she motioned her mother, who brought her the writing pad. She wrote the first line you were able to read: \u201cThank you.\u201d It was \u201cThank you.\u201d<\/p>\n

The second line is in Italian and it said, \u201cI missed you.\u201d She died a few days later.<\/p>\n

Marialuisa helped me get down in the depths of this and we walked through the depths while we were in pain together. Of course, tragedy was a big inspiration for me to say, \u201cLook, pain is really bad,\u201d but it\u2019s a great source of energy that you can use for doing good things for others.<\/p>\n

Unfortunately, in this line of business, if you\u2019re the head of the research institute, everybody comes to you for new things and, if you take personal care as Luke tells you, we have the opportunity\u2014the responsibility\u2014then. There are many places you can see and feel and touch and share and be reminded that you got a job to do. That\u2019s what this is all about.<\/p>\n

Q | As the leader of the Houston Methodist Research Institution, I imagine you don\u2019t have a lot of free time on your hands. What do you do in your free time?<\/strong><\/p>\n

A | I\u2019m writing theater productions. I write and I perform. The next one I\u2019m going to do is called, I\u2019m
\nNot an Actor. My idea is I\u2019m there in front of a lot of people and I talk to them like I\u2019m talking to you. I\u2019m telling true stories. When you\u2019ve got 2,000 people in a room, it\u2019s kind of hard to look everybody in the face, but that\u2019s where the challenge is. I have been through a lot. This has been a very difficult, very rewarding life and I think it\u2019s worth telling.<\/p>\n

Q | Why do these performances? Is it for the benefit of the audience or for you?<\/strong><\/p>\n

A | I think it has to be both. There has to be some emotional fracking. In some ways, there is a restlessness inside me and it is soothed by talking about things and sharing. You get a feeling of community.<\/p>\n

It\u2019s all part of the mission concept of life. Whether you\u2019re religious or not religious, it doesn\u2019t make any difference. It\u2019s all about service to others. It\u2019s the only thing that I find to be soothing for the soul. Nothing else.<\/p>\n

The only thing that brings any soothing\u2014if you have a restless soul, at least\u2014is when you get to do something for others and then think of another thing to do for others.<\/p>\n

Q | At UC Berkeley, they have these blue placards in the parking lots given to Nobel laureates for reserved parking spaces.<\/strong><\/p>\n

A | I had a blue placard too.<\/p>\n

Q | You did?<\/strong><\/p>\n

A | For the handicapped. While playing an intramural game, one of my students destroyed my right ankle, so I got the disabled person\u2019s parking permit for six months. They would say, \u201cYou see, I got you a blue placard.\u201d I wanted the other one!<\/p>\n

Q | Do you feel like you might be getting the placard anytime soon?<\/strong><\/p>\n

A | I\u2019ve met and I\u2019ve worked with a lot of Nobel laureates, more than 50 at this time, in physics, in chemistry, in medicine. I have a lot of respect for everybody and these are great people that have received the Nobel prizes, but I\u2019ve seen people get very sick when they start thinking about these sorts of things. I think it\u2019s very unhealthy.<\/p>\n

There\u2019s only one thing to think about: The people who are waiting for the drug. The patients. If you start thinking about anything else, it\u2019ll ruin your life. You get heartburn, ulcers. That is not something worth talking about, but sometimes people ask me the question\u2014especially students\u2014and I try to tell them, \u201cWho cares?\u201d If you start doing things for that, your life is going to be miserable whether you get it or not. If you build your life on the notion that you need to get an award, then you want some other award. It\u2019s like one car, two cars, three cars, who cares? There\u2019s only one thing: serve.<\/p>\n

Q | You have a Downton Abbey tumbler on a shelf in your office. What\u2019s the meaning behind it?<\/strong><\/p>\n

A | In Downton Abbey, there is one character I identify with very much. The gentleman\u2019s name is Mr. Carson. He is the butler in this environment of great aristocracy and big castles, which is where we are at the Houston Methodist Research Institute. I know my job. I\u2019m the butler. And I\u2019m very happy to be the butler and a servant.<\/p>\n","protected":false},"excerpt":{"rendered":"

MAURO FERRARI, PH.D., president and CEO of Houston Methodist Research Institute, is known for his revolutionary treatment of cancer using nanotechnology. Ferrari spoke with Pulse about \u2018disciplinary fracking,\u2019 what soothes his soul, and why he identifies with the butler from Downton Abbey. Q | You\u2019re an avid marathon runner, which requires a lot of mental […]<\/p>\n","protected":false},"author":15,"featured_media":8957,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[1],"tags":[88,1741,31],"yoast_head":"\nTMC Spotlight: Mauro Ferrari, Ph.D. - TMC News<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.tmc.edu\/news\/2017\/03\/tmc-spotlight-mauro-ferrari-ph-d\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"TMC Spotlight: Mauro Ferrari, Ph.D. - TMC News\" \/>\n<meta property=\"og:description\" content=\"MAURO FERRARI, PH.D., president and CEO of Houston Methodist Research Institute, is known for his revolutionary treatment of cancer using nanotechnology. 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