{"id":2546,"date":"2015-04-01T14:32:49","date_gmt":"2015-04-01T14:32:49","guid":{"rendered":"https:\/\/www.tmc.edu\/news\/designing-a-better-way-to-study-stomach-flu\/"},"modified":"2019-08-16T14:59:21","modified_gmt":"2019-08-16T14:59:21","slug":"designing-a-better-way-to-study-stomach-flu","status":"publish","type":"post","link":"https:\/\/www.tmc.edu\/news\/2015\/04\/designing-a-better-way-to-study-stomach-flu\/","title":{"rendered":"Designing a Better Way to Study Stomach Flu"},"content":{"rendered":"
\n
\n
\n
\n

Rice University bioengineers are teaming with colleagues from Baylor College of Medicine and The University of Texas MD Anderson Cancer Center to apply the latest techniques in tissue engineering toward the study of one of the most common and deadly human illnesses\u2014the stomach flu.<\/p>\n

The bacteria and viruses that cause acute gastroenteritis often come from contaminated food or water and result in cramps, nausea, diarrhea and vomiting. In medical terms, these pathogens fall under the heading of \u201chuman enteric disease,\u201d and while they may be common, they can also be deadly. Diarrheal diseases still account for about 17 percent of worldwide human deaths each year, and they are the second-leading killer of children five and younger.<\/p>\n

One roadblock to studying enteric pathogens like human rotaviruses and E. coli is that the organisms behave differently in humans than they do in animals typically used in medical research. Stem cell research has led to recent breakthroughs in the development of more realistic cell culture models, but there\u2019s room for improvement.<\/p>\n<\/div>\n

\n

\u201cInfectious-disease labs that study enteric disease need better models that faithfully simulate the physiology of the intestine,\u201d said Rice tissue engineering researcher Jane Grande-Allen, Ph.D., the Isabel C. Cameron Professor of Bioengineering. \u201cThis organ contains multiple types of cells that are arranged in complex patterns, and these tissues are constantly on the move. They contract and expand all the time, and we suspect some pathogens take advantage of that motion to mount their attacks.\u201d<\/p>\n

Thanks to a $5.1 million grant from the National Institutes of Health, Grande-Allen and colleagues at Baylor and MD Anderson are embarking on a five-year program to create a bioreactor that more closely simulates the complex tissues and dynamic movements of the intestinal track.<\/p>\n

\n
\n
\n
\n

\u201cThis kind of problem can only\u00a0be solved with teamwork because\u00a0it requires expertise in enteric disease, cell biology, tissue engineering, bioreactor design and more,\u201d said Baylor\u2019s Mary Estes, the Cullen Chair of Molecular and Human Virology and principal investigator on the grant from the National Institute of Allergy and Infectious Diseases. \u201cNo single institution has all of that expertise, but thanks to the resources in the Texas Medical Center, we have assembled a team that is uniquely qualified to meet this challenge.\u201d<\/p>\n<\/div>\n

\n

Grande-Allen said the team\u2019s five-year goal is to deliver a simple, easy-to- use and relatively inexpensive system that could be easily implemented by any infectious disease lab.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Rice University bioengineers are teaming with colleagues from Baylor College of Medicine and The University of Texas MD Anderson Cancer Center to apply the latest techniques in tissue engineering toward the study of one of the most common and deadly human illnesses\u2014the stomach flu. The bacteria and viruses that cause acute gastroenteritis often come from […]<\/p>\n","protected":false},"author":14,"featured_media":2547,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[1],"tags":[],"yoast_head":"\nDesigning a Better Way to Study Stomach Flu - TMC News<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.tmc.edu\/news\/2015\/04\/designing-a-better-way-to-study-stomach-flu\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Designing a Better Way to Study Stomach Flu - TMC News\" \/>\n<meta property=\"og:description\" content=\"Rice University bioengineers are teaming with colleagues from Baylor College of Medicine and The University of Texas MD Anderson Cancer Center to apply the latest techniques in tissue engineering toward the study of one of the most common and deadly human illnesses\u2014the stomach flu. The bacteria and viruses that cause acute gastroenteritis often come from […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.tmc.edu\/news\/2015\/04\/designing-a-better-way-to-study-stomach-flu\/\" \/>\n<meta property=\"og:site_name\" content=\"TMC News\" \/>\n<meta property=\"article:published_time\" content=\"2015-04-01T14:32:49+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2019-08-16T14:59:21+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.tmc.edu\/news\/wp-content\/uploads\/sites\/2\/2019\/06\/0316_NIH-GrandeAllen-lg.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1650\" \/>\n\t<meta property=\"og:image:height\" content=\"1100\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Shea Connelly\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Shea Connelly\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.tmc.edu\/news\/2015\/04\/designing-a-better-way-to-study-stomach-flu\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.tmc.edu\/news\/2015\/04\/designing-a-better-way-to-study-stomach-flu\/\"},\"author\":{\"name\":\"Shea Connelly\",\"@id\":\"https:\/\/www.tmc.edu\/news\/#\/schema\/person\/1efc1245df91906c0f248c5105d95739\"},\"headline\":\"Designing a Better Way to Study Stomach Flu\",\"datePublished\":\"2015-04-01T14:32:49+00:00\",\"dateModified\":\"2019-08-16T14:59:21+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.tmc.edu\/news\/2015\/04\/designing-a-better-way-to-study-stomach-flu\/\"},\"wordCount\":407,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/www.tmc.edu\/news\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.tmc.edu\/news\/2015\/04\/designing-a-better-way-to-study-stomach-flu\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.tmc.edu\/news\/wp-content\/uploads\/sites\/2\/2019\/06\/0316_NIH-GrandeAllen-lg.jpg\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.tmc.edu\/news\/2015\/04\/designing-a-better-way-to-study-stomach-flu\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.tmc.edu\/news\/2015\/04\/designing-a-better-way-to-study-stomach-flu\/\",\"url\":\"https:\/\/www.tmc.edu\/news\/2015\/04\/designing-a-better-way-to-study-stomach-flu\/\",\"name\":\"Designing a Better Way to Study Stomach Flu - TMC News\",\"isPartOf\":{\"@id\":\"https:\/\/www.tmc.edu\/news\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.tmc.edu\/news\/2015\/04\/designing-a-better-way-to-study-stomach-flu\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.tmc.edu\/news\/2015\/04\/designing-a-better-way-to-study-stomach-flu\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.tmc.edu\/news\/wp-content\/uploads\/sites\/2\/2019\/06\/0316_NIH-GrandeAllen-lg.jpg\",\"datePublished\":\"2015-04-01T14:32:49+00:00\",\"dateModified\":\"2019-08-16T14:59:21+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.tmc.edu\/news\/2015\/04\/designing-a-better-way-to-study-stomach-flu\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.tmc.edu\/news\/2015\/04\/designing-a-better-way-to-study-stomach-flu\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.tmc.edu\/news\/2015\/04\/designing-a-better-way-to-study-stomach-flu\/#primaryimage\",\"url\":\"https:\/\/www.tmc.edu\/news\/wp-content\/uploads\/sites\/2\/2019\/06\/0316_NIH-GrandeAllen-lg.jpg\",\"contentUrl\":\"https:\/\/www.tmc.edu\/news\/wp-content\/uploads\/sites\/2\/2019\/06\/0316_NIH-GrandeAllen-lg.jpg\",\"width\":1650,\"height\":1100},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.tmc.edu\/news\/2015\/04\/designing-a-better-way-to-study-stomach-flu\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.tmc.edu\/news\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Designing a Better Way to Study Stomach Flu\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.tmc.edu\/news\/#website\",\"url\":\"https:\/\/www.tmc.edu\/news\/\",\"name\":\"TMC News\",\"description\":\"Leader in Collaborative Medicine and Research\",\"publisher\":{\"@id\":\"https:\/\/www.tmc.edu\/news\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.tmc.edu\/news\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.tmc.edu\/news\/#organization\",\"name\":\"TMC News\",\"url\":\"https:\/\/www.tmc.edu\/news\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.tmc.edu\/news\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.tmc.edu\/news\/wp-content\/uploads\/sites\/2\/2020\/01\/TMC_News_RGB.png\",\"contentUrl\":\"https:\/\/www.tmc.edu\/news\/wp-content\/uploads\/sites\/2\/2020\/01\/TMC_News_RGB.png\",\"width\":1303,\"height\":266,\"caption\":\"TMC News\"},\"image\":{\"@id\":\"https:\/\/www.tmc.edu\/news\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.tmc.edu\/news\/#\/schema\/person\/1efc1245df91906c0f248c5105d95739\",\"name\":\"Shea Connelly\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.tmc.edu\/news\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/570211c6e212591d873efced4b00a19e?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/570211c6e212591d873efced4b00a19e?s=96&d=mm&r=g\",\"caption\":\"Shea Connelly\"},\"url\":\"https:\/\/www.tmc.edu\/news\/author\/sconnelly\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Designing a Better Way to Study Stomach Flu - TMC News","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.tmc.edu\/news\/2015\/04\/designing-a-better-way-to-study-stomach-flu\/","og_locale":"en_US","og_type":"article","og_title":"Designing a Better Way to Study Stomach Flu - TMC News","og_description":"Rice University bioengineers are teaming with colleagues from Baylor College of Medicine and The University of Texas MD Anderson Cancer Center to apply the latest techniques in tissue engineering toward the study of one of the most common and deadly human illnesses\u2014the stomach flu. The bacteria and viruses that cause acute gastroenteritis often come from […]","og_url":"https:\/\/www.tmc.edu\/news\/2015\/04\/designing-a-better-way-to-study-stomach-flu\/","og_site_name":"TMC News","article_published_time":"2015-04-01T14:32:49+00:00","article_modified_time":"2019-08-16T14:59:21+00:00","og_image":[{"width":1650,"height":1100,"url":"https:\/\/www.tmc.edu\/news\/wp-content\/uploads\/sites\/2\/2019\/06\/0316_NIH-GrandeAllen-lg.jpg","type":"image\/jpeg"}],"author":"Shea Connelly","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Shea Connelly","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.tmc.edu\/news\/2015\/04\/designing-a-better-way-to-study-stomach-flu\/#article","isPartOf":{"@id":"https:\/\/www.tmc.edu\/news\/2015\/04\/designing-a-better-way-to-study-stomach-flu\/"},"author":{"name":"Shea Connelly","@id":"https:\/\/www.tmc.edu\/news\/#\/schema\/person\/1efc1245df91906c0f248c5105d95739"},"headline":"Designing a Better Way to Study Stomach Flu","datePublished":"2015-04-01T14:32:49+00:00","dateModified":"2019-08-16T14:59:21+00:00","mainEntityOfPage":{"@id":"https:\/\/www.tmc.edu\/news\/2015\/04\/designing-a-better-way-to-study-stomach-flu\/"},"wordCount":407,"commentCount":0,"publisher":{"@id":"https:\/\/www.tmc.edu\/news\/#organization"},"image":{"@id":"https:\/\/www.tmc.edu\/news\/2015\/04\/designing-a-better-way-to-study-stomach-flu\/#primaryimage"},"thumbnailUrl":"https:\/\/www.tmc.edu\/news\/wp-content\/uploads\/sites\/2\/2019\/06\/0316_NIH-GrandeAllen-lg.jpg","inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/www.tmc.edu\/news\/2015\/04\/designing-a-better-way-to-study-stomach-flu\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/www.tmc.edu\/news\/2015\/04\/designing-a-better-way-to-study-stomach-flu\/","url":"https:\/\/www.tmc.edu\/news\/2015\/04\/designing-a-better-way-to-study-stomach-flu\/","name":"Designing a Better Way to Study Stomach Flu - TMC News","isPartOf":{"@id":"https:\/\/www.tmc.edu\/news\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.tmc.edu\/news\/2015\/04\/designing-a-better-way-to-study-stomach-flu\/#primaryimage"},"image":{"@id":"https:\/\/www.tmc.edu\/news\/2015\/04\/designing-a-better-way-to-study-stomach-flu\/#primaryimage"},"thumbnailUrl":"https:\/\/www.tmc.edu\/news\/wp-content\/uploads\/sites\/2\/2019\/06\/0316_NIH-GrandeAllen-lg.jpg","datePublished":"2015-04-01T14:32:49+00:00","dateModified":"2019-08-16T14:59:21+00:00","breadcrumb":{"@id":"https:\/\/www.tmc.edu\/news\/2015\/04\/designing-a-better-way-to-study-stomach-flu\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.tmc.edu\/news\/2015\/04\/designing-a-better-way-to-study-stomach-flu\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.tmc.edu\/news\/2015\/04\/designing-a-better-way-to-study-stomach-flu\/#primaryimage","url":"https:\/\/www.tmc.edu\/news\/wp-content\/uploads\/sites\/2\/2019\/06\/0316_NIH-GrandeAllen-lg.jpg","contentUrl":"https:\/\/www.tmc.edu\/news\/wp-content\/uploads\/sites\/2\/2019\/06\/0316_NIH-GrandeAllen-lg.jpg","width":1650,"height":1100},{"@type":"BreadcrumbList","@id":"https:\/\/www.tmc.edu\/news\/2015\/04\/designing-a-better-way-to-study-stomach-flu\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.tmc.edu\/news\/"},{"@type":"ListItem","position":2,"name":"Designing a Better Way to Study Stomach Flu"}]},{"@type":"WebSite","@id":"https:\/\/www.tmc.edu\/news\/#website","url":"https:\/\/www.tmc.edu\/news\/","name":"TMC News","description":"Leader in Collaborative Medicine and Research","publisher":{"@id":"https:\/\/www.tmc.edu\/news\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.tmc.edu\/news\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.tmc.edu\/news\/#organization","name":"TMC News","url":"https:\/\/www.tmc.edu\/news\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.tmc.edu\/news\/#\/schema\/logo\/image\/","url":"https:\/\/www.tmc.edu\/news\/wp-content\/uploads\/sites\/2\/2020\/01\/TMC_News_RGB.png","contentUrl":"https:\/\/www.tmc.edu\/news\/wp-content\/uploads\/sites\/2\/2020\/01\/TMC_News_RGB.png","width":1303,"height":266,"caption":"TMC News"},"image":{"@id":"https:\/\/www.tmc.edu\/news\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/www.tmc.edu\/news\/#\/schema\/person\/1efc1245df91906c0f248c5105d95739","name":"Shea Connelly","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.tmc.edu\/news\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/570211c6e212591d873efced4b00a19e?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/570211c6e212591d873efced4b00a19e?s=96&d=mm&r=g","caption":"Shea Connelly"},"url":"https:\/\/www.tmc.edu\/news\/author\/sconnelly\/"}]}},"acf":[],"_links":{"self":[{"href":"https:\/\/www.tmc.edu\/news\/wp-json\/wp\/v2\/posts\/2546"}],"collection":[{"href":"https:\/\/www.tmc.edu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tmc.edu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tmc.edu\/news\/wp-json\/wp\/v2\/users\/14"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tmc.edu\/news\/wp-json\/wp\/v2\/comments?post=2546"}],"version-history":[{"count":0,"href":"https:\/\/www.tmc.edu\/news\/wp-json\/wp\/v2\/posts\/2546\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.tmc.edu\/news\/wp-json\/wp\/v2\/media\/2547"}],"wp:attachment":[{"href":"https:\/\/www.tmc.edu\/news\/wp-json\/wp\/v2\/media?parent=2546"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tmc.edu\/news\/wp-json\/wp\/v2\/categories?post=2546"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tmc.edu\/news\/wp-json\/wp\/v2\/tags?post=2546"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}