{"id":24691,"date":"2019-06-03T18:04:12","date_gmt":"2019-06-03T18:04:12","guid":{"rendered":"https:\/\/www.tmc.edu\/news\/2019\/06\/in-the-lab-with-scientist-doris-taylor-and-ghost-hearts\/"},"modified":"2019-08-28T16:10:42","modified_gmt":"2019-08-28T16:10:42","slug":"in-the-lab-with-scientist-doris-taylor-and-ghost-hearts","status":"publish","type":"post","link":"https:\/\/www.tmc.edu\/news\/2019\/06\/in-the-lab-with-scientist-doris-taylor-and-ghost-hearts\/","title":{"rendered":"In the lab with scientist Doris Taylor, Ph.D., and “ghost hearts”"},"content":{"rendered":"

A small human-sized heart hangs suspended in a bioreactor behind a maze of locked doors in Doris Taylor<\/a>\u2019s lab at the Texas Heart\u00a0Institute<\/a> (THI). It is void of color, drained of blood and cells. All that is left is its natural scaffold of extracellular matrix, fully intact.<\/p>\n

Taylor, who is the director of regenerative medicine research at THI, has already created more than 100 of these \u201cghost hearts\u201d\u2014and she intends to keep going, pumping each of them\u00a0full of hundreds of millions of stem cells, hooking them up to artificial lungs and a blood pump, then watching them grow. Eventually, she believes, scientists will use this technique to create tailor-made organs for human heart transplants using a patient\u2019s own stem cells. This could mean an end to organ shortages and anti-rejection drugs, as well as a revolution in cardiovascular surgery.<\/p>\n

But bringing one bold new idea to fruition means finding solutions for all the large and small problems that arise along the way.<\/p>\n

\u201cTen years ago, when we discovered the concept of building a ghost heart, I thought stem cell biology had advanced enough that we would be able to just take stem cells, put them in the heart, and do something cool. It\u2019s taken us 10 years to develop methods to just generate enough stem cells to transplant a meaningful number in the heart,\u201d Taylor said, adding that they have now developed the ability to grow over two billion\u00a0human-induced pluripotent stem cell-derived cardiomyocytes a week.<\/p>\n

\u201cWhich is unheard of,\u201d Taylor said.<\/p>\n

Cardiomyocytes are heart muscle cells. Induced pluripotent stem cells (iPSCs) are adult cells that have been genetically reprogrammed to mimic embryonic stem cells, though iPSCs have not yet been differentiated, meaning they have not started the process of becoming specialized cells. In other words, iPSCs are cells with an opportunity for a fresh start, which is necessary for growing new, healthy organs.<\/p>\n

Generating the sheer number of cells required for each heart is just one of the many hurdles Taylor and her team have faced. They have also had to design and create their own methods for sterilizing the tools and environments to keep the hearts clean and healthy as the stem cells mature. But they worked through that, too, and can now keep a heart going for 60 days\u2014a cap she\u2019s had to implement because of the availability of resources. Each custom bioreactor set-up is expensive, so her team must stop one in order to start a new one.<\/p>\n

But, she said, they are exceptionally close to successfully building a working, human-sized heart. And in the meantime, the knowledge they\u2019ve gained pursuing this goal has led them to the doorstep of many other medical challenges.<\/p>\n

\"\"

Taylor holds a ghost heart over a bucket containing a solution that is used to wash the cells from the heart scaffold. The attached tubing delivers this solution to the heart.<\/p><\/div>\n

Location, location, location<\/h2>\n

\u201cWe\u2019ve learned that if we put the same stem\u00a0cells in the atrium or the ventricle, they become different cells, so the matrix seems to have cues that drive differentiation and maturation, which is really cool,\u201d said Taylor, a scientist with a Ph.D. in pharmacology. \u201cIn human hearts where heart failure is present, and where different kinds of heart failure is present, the scaffold is different. So all\u00a0of a sudden, we\u2019re learning at an intriguing level what we already knew kind of a priori, which is that stem cells respond to their environment to become what they find themselves surrounded by.\u201d<\/p>\n

Taylor hypothesized that one of the reasons cell therapy has yielded only modest results in repairing damaged hearts is because the stem\u00a0cells are being placed in unhealthy organs.<\/p>\n

\u201cWe\u2019re taking these immature cells, stem or progenitor cells, and we\u2019re putting them in a scar. And we\u2019re saying, \u2018Hey, grow up and become a healthy heart,\u2019\u201d Taylor said. \u201cBut what if we put them in a matrix before we put them in the heart and allow them to mature first?\u201d<\/p>\n

Her lab has been working on a cardiac patch that may be more successful than traditional cell therapy techniques. Currently, they are pursuing two different methods: the first involves taking\u00a0a piece of decellularized healthy heart, cutting it out, then sewing it onto the surface of the heart as a patch; the second involves grinding up one of the ghost hearts and creating a powder that they then convert into a gel that is injected into the scarred or damaged area of the heart.<\/p>\n

\u201cIt\u2019s really about putting things in the right environment and letting them do their thing,\u201d Taylor said. \u201cI call it the real estate approach to cell therapy. Location, location, location.\u201d<\/p>\n

A step further<\/h2>\n

There\u2019s more\u2014in fact, potential applications for the team\u2019s discoveries are vast.<\/p>\n

After noticing that individuals with heart failure seemed to have different matrices than those with healthy hearts, Taylor wanted to compare the matrices in the hearts of animals. What her team found was that in young animals, the matrices of\u00a0the heart, liver and kidneys of females were stiffer than those of their male counterparts.<\/p>\n

Taylor was puzzled. Why would that be?<\/p>\n

\u201cI started thinking about the fact that when women get pregnant, their blood volume goes way up,\u201d she said. \u201cAnd if your heart has to pump against that blood volume, you need something that\u2019s tougher. We also found out that if we look in older males and females, the males catch up with the females later in life.\u201d<\/p>\n

Taylor took it a step further, aware that a disproportionate number of women suffer from a type of heart failure called preserved ejection fraction systolic dysfunction, in which the heart muscle contracts normally, but the ventricles do not relax as they should.<\/p>\n

\u201cIt\u2019s the ultimate irony,\u201d she joked. \u201cWomen can\u2019t relax as well.\u201d<\/p>\n

It turns out, there is a protein in the heart muscle responsible for that stiffness.<\/p>\n

\u201cWe\u2019ve recently found that the extracellular matrix determines how much of that protein\u00a0you have,\u201d Taylor said. \u201cThis type of heart failure is three times more prevalent in women, and I think it\u2019s because the matrix is different, so we\u2019ve developed a treatment that we hope to try over the next year in preclinical studies that we think will reverse that.\u201d<\/p>\n

Currently, Taylor said, there are no treatment\u00a0options for this type of heart failure.<\/p>\n

\u201cIt\u2019s all because we looked at the matrix and\u00a0saw that there is this underlying structural difference that tells cells how to behave. Again, it\u2019s about environment\u2014location,\u201d she said.<\/p>\n

Taylor\u2019s lab is also learning that lifestyle can impact the health of a person\u2019s stem cells.<\/p>\n

\u201cWe\u2019ve found that smoking, diabetes, hypertension\u2014all of those things change your bone marrow, they change the cells that are there. They will increase inflammatory cells and decrease positive cells, and we\u2019ve been able to show … that if you look at the onset of heart disease and the loss of some of these stem cells, they absolutely mirror each other,\u201d Taylor said. \u201cAnd so I say that aging, and a lot of the diseases associated with aging,\u00a0are a failure of endogenous repair, and a failure of your stem cells.\u201d<\/p>\n

Taylor applied these lessons to her own life.<\/p>\n

\u201cI was involved in a clinical study that shows when you exercise you increase the number of stem cells in your blood,\u201d she said. \u201cAnd I did a study with a colleague in California where we studied acupuncture. It was a small number of women, but in the women who got acupuncture versus sham acupuncture, the number of circulating progenitor cells went up\u2014so all these things we\u2019ve been told to do to decrease stress, it actually does increase the number of circulating cells.\u201d<\/p>\n

Go for the home run<\/h2>\n

Despite naysayers, Taylor has always believed she could rebuild an organ from the ground up. She believes in the complexity of \u201cnature\u2019s tools\u201d and that pre-existing structural compositions are far superior to any designed by the human hand.<\/p>\n

One of the things Taylor is most proud of is that her lab\u2019s more mature hearts are now growing fat on the outside of the muscle.<\/p>\n

\u201cIt\u2019s real,\u201d she said, adding that at this point, creating an organ is now just a matter of money and time.<\/p>\n

\u201cIt\u2019s about slogging through it right now, doing it over and over and over and improving a little bit every time,\u201d Taylor said. \u201cBut that is expensive. … Right now, building a small, pediatric-sized humanized heart costs us\u00a0sixty to seventy thousand dollars.\u201d<\/p>\n

With the right funding\u2014Taylor said her research isn\u2019t eligible for the usual types of National Institutes of Health<\/a> funding because it\u2019s not technically hypothesis-driven\u2014Taylor could envision the technique moving quickly to preclinical studies. Still, she emphasized how grateful she is that THI has supported her high-risk, high-reward research.<\/p>\n

\u201cThere\u2019s a 50 year history of trying to build solutions for heart disease here,\u201d she said. \u201cThat\u2019s why I came here and that\u2019s what has enabled us to\u00a0get to this point.\u201d<\/p>\n

Taylor said that her work is on an exponential\u00a0growth curve, and that she and her team feel like they are more in a process at this point than an experiment.<\/p>\n

\u201cIt\u2019s a good problem to have, but it\u2019s a hard\u00a0scientific place to be,\u201d she said.<\/p>\n

It doesn\u2019t help, she added, that she chose to pursue such a complex challenge.<\/p>\n

\u201cIt\u2019s very different building a biologic device than it is building a mechanical device,\u201d Taylor said. \u201cBiology is variable, and if you build a mechanical device, you assume it\u2019s going to act the same way every single time you build it. But\u00a0if you build a biologic heart, you have to prove\u00a0it\u2019s going to act similarly, with a certain degree\u00a0of variability. … Not only do we have to figure out how to build a heart, but we have to figure out how to measure building a heart, which nobody\u2019s ever done before, so there aren\u2019t tools out there to do\u00a0it. It\u2019s really about constantly having to rebuild everything around you, because none of it exists.\u201d<\/p>\n

In the end, Taylor is working to help keep people and their hearts as healthy as possible.<\/p>\n

\u201cMy approach to science has been: go for the home run, and if it works, great, and if it doesn\u2019t, everything you learned along the way is going to open new doors,\u201d Taylor said.<\/p>\n","protected":false},"excerpt":{"rendered":"

A small human-sized heart hangs suspended in a bioreactor behind a maze of locked doors in Doris Taylor\u2019s lab at the Texas Heart\u00a0Institute (THI). It is void of color, drained of blood and cells. All that is left is its natural scaffold of extracellular matrix, fully intact. Taylor, who is the director of regenerative medicine […]<\/p>\n","protected":false},"author":3,"featured_media":24692,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[1],"tags":[1657,3775,593,594,28],"yoast_head":"\nIn the lab with scientist Doris Taylor, Ph.D., and "ghost hearts" - TMC News<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.tmc.edu\/news\/2019\/06\/in-the-lab-with-scientist-doris-taylor-and-ghost-hearts\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"In the lab with scientist Doris Taylor, Ph.D., and "ghost hearts" - TMC News\" \/>\n<meta property=\"og:description\" content=\"A small human-sized heart hangs suspended in a bioreactor behind a maze of locked doors in Doris Taylor\u2019s lab at the Texas Heart\u00a0Institute (THI). It is void of color, drained of blood and cells. All that is left is its natural scaffold of extracellular matrix, fully intact. Taylor, who is the director of regenerative medicine […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.tmc.edu\/news\/2019\/06\/in-the-lab-with-scientist-doris-taylor-and-ghost-hearts\/\" \/>\n<meta property=\"og:site_name\" content=\"TMC News\" \/>\n<meta property=\"article:published_time\" content=\"2019-06-03T18:04:12+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2019-08-28T16:10:42+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.tmc.edu\/news\/wp-content\/uploads\/sites\/2\/2019\/08\/20190426_ghost_heart_16.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"800\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Alexandra Becker\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Alexandra Becker\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"9 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.tmc.edu\/news\/2019\/06\/in-the-lab-with-scientist-doris-taylor-and-ghost-hearts\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.tmc.edu\/news\/2019\/06\/in-the-lab-with-scientist-doris-taylor-and-ghost-hearts\/\"},\"author\":{\"name\":\"Alexandra Becker\",\"@id\":\"https:\/\/www.tmc.edu\/news\/#\/schema\/person\/ee892c47c28b157bcf0e4f841b382669\"},\"headline\":\"In the lab with scientist Doris Taylor, Ph.D., and “ghost hearts”\",\"datePublished\":\"2019-06-03T18:04:12+00:00\",\"dateModified\":\"2019-08-28T16:10:42+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.tmc.edu\/news\/2019\/06\/in-the-lab-with-scientist-doris-taylor-and-ghost-hearts\/\"},\"wordCount\":1792,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/www.tmc.edu\/news\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.tmc.edu\/news\/2019\/06\/in-the-lab-with-scientist-doris-taylor-and-ghost-hearts\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.tmc.edu\/news\/wp-content\/uploads\/sites\/2\/2019\/08\/20190426_ghost_heart_16.jpg\",\"keywords\":[\"Doris Taylor\",\"ghost heart\",\"regenerative medicine\",\"stem cells\",\"Texas Heart Institute\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.tmc.edu\/news\/2019\/06\/in-the-lab-with-scientist-doris-taylor-and-ghost-hearts\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.tmc.edu\/news\/2019\/06\/in-the-lab-with-scientist-doris-taylor-and-ghost-hearts\/\",\"url\":\"https:\/\/www.tmc.edu\/news\/2019\/06\/in-the-lab-with-scientist-doris-taylor-and-ghost-hearts\/\",\"name\":\"In the lab with scientist Doris Taylor, Ph.D., and \\\"ghost hearts\\\" - TMC News\",\"isPartOf\":{\"@id\":\"https:\/\/www.tmc.edu\/news\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.tmc.edu\/news\/2019\/06\/in-the-lab-with-scientist-doris-taylor-and-ghost-hearts\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.tmc.edu\/news\/2019\/06\/in-the-lab-with-scientist-doris-taylor-and-ghost-hearts\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.tmc.edu\/news\/wp-content\/uploads\/sites\/2\/2019\/08\/20190426_ghost_heart_16.jpg\",\"datePublished\":\"2019-06-03T18:04:12+00:00\",\"dateModified\":\"2019-08-28T16:10:42+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.tmc.edu\/news\/2019\/06\/in-the-lab-with-scientist-doris-taylor-and-ghost-hearts\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.tmc.edu\/news\/2019\/06\/in-the-lab-with-scientist-doris-taylor-and-ghost-hearts\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.tmc.edu\/news\/2019\/06\/in-the-lab-with-scientist-doris-taylor-and-ghost-hearts\/#primaryimage\",\"url\":\"https:\/\/www.tmc.edu\/news\/wp-content\/uploads\/sites\/2\/2019\/08\/20190426_ghost_heart_16.jpg\",\"contentUrl\":\"https:\/\/www.tmc.edu\/news\/wp-content\/uploads\/sites\/2\/2019\/08\/20190426_ghost_heart_16.jpg\",\"width\":1200,\"height\":800},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.tmc.edu\/news\/2019\/06\/in-the-lab-with-scientist-doris-taylor-and-ghost-hearts\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.tmc.edu\/news\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"In the lab with scientist Doris Taylor, Ph.D., and “ghost hearts”\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.tmc.edu\/news\/#website\",\"url\":\"https:\/\/www.tmc.edu\/news\/\",\"name\":\"TMC News\",\"description\":\"Leader in Collaborative Medicine and Research\",\"publisher\":{\"@id\":\"https:\/\/www.tmc.edu\/news\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.tmc.edu\/news\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.tmc.edu\/news\/#organization\",\"name\":\"TMC News\",\"url\":\"https:\/\/www.tmc.edu\/news\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.tmc.edu\/news\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.tmc.edu\/news\/wp-content\/uploads\/sites\/2\/2020\/01\/TMC_News_RGB.png\",\"contentUrl\":\"https:\/\/www.tmc.edu\/news\/wp-content\/uploads\/sites\/2\/2020\/01\/TMC_News_RGB.png\",\"width\":1303,\"height\":266,\"caption\":\"TMC News\"},\"image\":{\"@id\":\"https:\/\/www.tmc.edu\/news\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.tmc.edu\/news\/#\/schema\/person\/ee892c47c28b157bcf0e4f841b382669\",\"name\":\"Alexandra Becker\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.tmc.edu\/news\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/4cb7f70c8bc1f87914b8e0f0e941df05?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/4cb7f70c8bc1f87914b8e0f0e941df05?s=96&d=mm&r=g\",\"caption\":\"Alexandra Becker\"},\"url\":\"https:\/\/www.tmc.edu\/news\/author\/alexandra\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"In the lab with scientist Doris Taylor, Ph.D., and \"ghost hearts\" - TMC News","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.tmc.edu\/news\/2019\/06\/in-the-lab-with-scientist-doris-taylor-and-ghost-hearts\/","og_locale":"en_US","og_type":"article","og_title":"In the lab with scientist Doris Taylor, Ph.D., and \"ghost hearts\" - TMC News","og_description":"A small human-sized heart hangs suspended in a bioreactor behind a maze of locked doors in Doris Taylor\u2019s lab at the Texas Heart\u00a0Institute (THI). It is void of color, drained of blood and cells. All that is left is its natural scaffold of extracellular matrix, fully intact. Taylor, who is the director of regenerative medicine […]","og_url":"https:\/\/www.tmc.edu\/news\/2019\/06\/in-the-lab-with-scientist-doris-taylor-and-ghost-hearts\/","og_site_name":"TMC News","article_published_time":"2019-06-03T18:04:12+00:00","article_modified_time":"2019-08-28T16:10:42+00:00","og_image":[{"width":1200,"height":800,"url":"https:\/\/www.tmc.edu\/news\/wp-content\/uploads\/sites\/2\/2019\/08\/20190426_ghost_heart_16.jpg","type":"image\/jpeg"}],"author":"Alexandra Becker","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Alexandra Becker","Est. reading time":"9 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.tmc.edu\/news\/2019\/06\/in-the-lab-with-scientist-doris-taylor-and-ghost-hearts\/#article","isPartOf":{"@id":"https:\/\/www.tmc.edu\/news\/2019\/06\/in-the-lab-with-scientist-doris-taylor-and-ghost-hearts\/"},"author":{"name":"Alexandra Becker","@id":"https:\/\/www.tmc.edu\/news\/#\/schema\/person\/ee892c47c28b157bcf0e4f841b382669"},"headline":"In the lab with scientist Doris Taylor, Ph.D., and “ghost hearts”","datePublished":"2019-06-03T18:04:12+00:00","dateModified":"2019-08-28T16:10:42+00:00","mainEntityOfPage":{"@id":"https:\/\/www.tmc.edu\/news\/2019\/06\/in-the-lab-with-scientist-doris-taylor-and-ghost-hearts\/"},"wordCount":1792,"commentCount":0,"publisher":{"@id":"https:\/\/www.tmc.edu\/news\/#organization"},"image":{"@id":"https:\/\/www.tmc.edu\/news\/2019\/06\/in-the-lab-with-scientist-doris-taylor-and-ghost-hearts\/#primaryimage"},"thumbnailUrl":"https:\/\/www.tmc.edu\/news\/wp-content\/uploads\/sites\/2\/2019\/08\/20190426_ghost_heart_16.jpg","keywords":["Doris Taylor","ghost heart","regenerative medicine","stem cells","Texas Heart Institute"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/www.tmc.edu\/news\/2019\/06\/in-the-lab-with-scientist-doris-taylor-and-ghost-hearts\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/www.tmc.edu\/news\/2019\/06\/in-the-lab-with-scientist-doris-taylor-and-ghost-hearts\/","url":"https:\/\/www.tmc.edu\/news\/2019\/06\/in-the-lab-with-scientist-doris-taylor-and-ghost-hearts\/","name":"In the lab with scientist Doris Taylor, Ph.D., and \"ghost hearts\" - TMC News","isPartOf":{"@id":"https:\/\/www.tmc.edu\/news\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.tmc.edu\/news\/2019\/06\/in-the-lab-with-scientist-doris-taylor-and-ghost-hearts\/#primaryimage"},"image":{"@id":"https:\/\/www.tmc.edu\/news\/2019\/06\/in-the-lab-with-scientist-doris-taylor-and-ghost-hearts\/#primaryimage"},"thumbnailUrl":"https:\/\/www.tmc.edu\/news\/wp-content\/uploads\/sites\/2\/2019\/08\/20190426_ghost_heart_16.jpg","datePublished":"2019-06-03T18:04:12+00:00","dateModified":"2019-08-28T16:10:42+00:00","breadcrumb":{"@id":"https:\/\/www.tmc.edu\/news\/2019\/06\/in-the-lab-with-scientist-doris-taylor-and-ghost-hearts\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.tmc.edu\/news\/2019\/06\/in-the-lab-with-scientist-doris-taylor-and-ghost-hearts\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.tmc.edu\/news\/2019\/06\/in-the-lab-with-scientist-doris-taylor-and-ghost-hearts\/#primaryimage","url":"https:\/\/www.tmc.edu\/news\/wp-content\/uploads\/sites\/2\/2019\/08\/20190426_ghost_heart_16.jpg","contentUrl":"https:\/\/www.tmc.edu\/news\/wp-content\/uploads\/sites\/2\/2019\/08\/20190426_ghost_heart_16.jpg","width":1200,"height":800},{"@type":"BreadcrumbList","@id":"https:\/\/www.tmc.edu\/news\/2019\/06\/in-the-lab-with-scientist-doris-taylor-and-ghost-hearts\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.tmc.edu\/news\/"},{"@type":"ListItem","position":2,"name":"In the lab with scientist Doris Taylor, Ph.D., and “ghost hearts”"}]},{"@type":"WebSite","@id":"https:\/\/www.tmc.edu\/news\/#website","url":"https:\/\/www.tmc.edu\/news\/","name":"TMC News","description":"Leader in Collaborative Medicine and Research","publisher":{"@id":"https:\/\/www.tmc.edu\/news\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.tmc.edu\/news\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.tmc.edu\/news\/#organization","name":"TMC News","url":"https:\/\/www.tmc.edu\/news\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.tmc.edu\/news\/#\/schema\/logo\/image\/","url":"https:\/\/www.tmc.edu\/news\/wp-content\/uploads\/sites\/2\/2020\/01\/TMC_News_RGB.png","contentUrl":"https:\/\/www.tmc.edu\/news\/wp-content\/uploads\/sites\/2\/2020\/01\/TMC_News_RGB.png","width":1303,"height":266,"caption":"TMC News"},"image":{"@id":"https:\/\/www.tmc.edu\/news\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/www.tmc.edu\/news\/#\/schema\/person\/ee892c47c28b157bcf0e4f841b382669","name":"Alexandra Becker","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.tmc.edu\/news\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/4cb7f70c8bc1f87914b8e0f0e941df05?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/4cb7f70c8bc1f87914b8e0f0e941df05?s=96&d=mm&r=g","caption":"Alexandra Becker"},"url":"https:\/\/www.tmc.edu\/news\/author\/alexandra\/"}]}},"acf":[],"_links":{"self":[{"href":"https:\/\/www.tmc.edu\/news\/wp-json\/wp\/v2\/posts\/24691"}],"collection":[{"href":"https:\/\/www.tmc.edu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tmc.edu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tmc.edu\/news\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tmc.edu\/news\/wp-json\/wp\/v2\/comments?post=24691"}],"version-history":[{"count":0,"href":"https:\/\/www.tmc.edu\/news\/wp-json\/wp\/v2\/posts\/24691\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.tmc.edu\/news\/wp-json\/wp\/v2\/media\/24692"}],"wp:attachment":[{"href":"https:\/\/www.tmc.edu\/news\/wp-json\/wp\/v2\/media?parent=24691"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tmc.edu\/news\/wp-json\/wp\/v2\/categories?post=24691"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tmc.edu\/news\/wp-json\/wp\/v2\/tags?post=24691"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}