{"id":11291,"date":"2018-03-09T21:24:40","date_gmt":"2018-03-09T21:24:40","guid":{"rendered":"https:\/\/www.tmc.edu\/news\/solutions-pen-detects-cancer-real-time\/"},"modified":"2019-08-16T15:03:54","modified_gmt":"2019-08-16T15:03:54","slug":"solutions-pen-detects-cancer-real-time","status":"publish","type":"post","link":"https:\/\/www.tmc.edu\/news\/2018\/03\/solutions-pen-detects-cancer-real-time\/","title":{"rendered":"Solutions: A Pen that Detects Cancer in Real Time"},"content":{"rendered":"

One telephone call triggered\u00a0a new device that aims\u00a0to give surgeons more precise\u00a0diagnostic information about\u00a0what to cut and what to preserve\u00a0during cancer surgery.<\/p>\n

Livia Schiavinato Eberlin, Ph.D.,\u00a0assistant professor of chemistry\u00a0at The University of Texas (UT) at\u00a0Austin, made that phone call, and\u00a0James Suliburk, M.D., associate\u00a0professor and head of endocrine surgery\u00a0at Baylor College of Medicine, answered it.<\/p>\n

\u201cShe wanted to test a mass spectrometer\u00a0to see if it would rule in or\u00a0rule out cancer,\u201d Suliburk said.\u00a0\u201cI responded with \u2018Yes!\u2019\u201d<\/p>\n

Mass spectrometry\u00a0is a fairly\u00a0new application\u00a0within clinical\u00a0settings,\u00a0Suliburk\u00a0said. A mass\u00a0spectrometer\u00a0measures\u00a0characteristics\u00a0of individual molecules.\u00a0Eberlin wanted\u00a0to test the MasSpec Pen,\u00a0a handheld device that can detect\u00a0cancer by touch\u2014in real time.<\/p>\n

\"James

James Suliburk, M.D., associate professor and head of endocrine at Baylor College of Medicine.<\/p><\/div>\n

A surgeon holds the MasSpec Pen against the\u00a0patient\u2019s tissue\u00a0and uses a\u00a0foot pedal to\u00a0trigger the\u00a0automated\u00a0analysis, waiting\u00a0a few seconds\u00a0for a result. The pen\u00a0releases a drop of water\u00a0onto the tissue, and small molecules\u00a0from the tissue migrate into\u00a0the water.<\/p>\n

Then the device drives\u00a0the water sample into the mass\u00a0spectrometer, which reads thousands\u00a0of molecules as a molecular\u00a0fingerprint. When the MasSpec Pen\u00a0completes the tissue analysis, the\u00a0words \u201cNormal\u201d or \u201cCancer\u201d appear\u00a0automatically on a computer screen.\u00a0Surgeons then know which tissue to\u00a0remove and which tissue to leave in\u00a0the body.<\/p>\n

Significantly, the pen allows\u00a0surgeons to analyze tissue\u00a0while it\u2019s still in the body,\u00a0unlike frozen section analysis,\u00a0the current method for diagnosing\u00a0cancer during surgery\u00a0and determining the boundary\u00a0between cancerous tissue\u00a0and healthy tissue.<\/p>\n

The frozen section process,\u00a0which has been around for\u00a0100 years, involves the removal\u00a0of tissue or an organ so it can be\u00a0studied under a microscope. Frozen\u00a0section is often slow and sometimes\u00a0inaccurate, and each sample\u00a0can take a pathologist as much\u00a0as 45 minutes to prepare and interpret,\u00a0increasing the patient\u2019s risk\u00a0for infection.<\/p>\n

In addition, frozen section\u00a0analysis is difficult to interpret for\u00a0some types of cancers. And once\u00a0the tissue or organ is removed, it\u00a0can\u2019t be put back, said Suliburk, who\u00a0often operates on the thyroid.<\/p>\n

\u201cWe operate to remove a part\u00a0of or all of the thyroid,\u201d he said.\u00a0\u201cWhat we find is that a majority of\u00a0the patients will not have cancer,\u00a0but until now, our diagnostics were\u00a0not to the point, yet, where we could\u00a0improve that procedure.\u201d<\/p>\n

But with the MasSpec Pen, cancerous\u00a0tissue is accurately\u00a0identified in\u00a0about 10 seconds,\u00a0he said.<\/p>\n

\"Livia

Livia Schiavinato Eberlin, Ph.D., chemistry professor at The University of Texas at Austin.<\/p><\/div>\n

The MasSpec\u00a0Pen was developed\u00a0by a team\u00a0of scientists,\u00a0surgeons and\u00a0James Suliburk, engineers from UT Austin, Baylor\u00a0and The University of Texas MD\u00a0Anderson Cancer Center.<\/p>\n

Led by\u00a0Eberlin, the team has demonstrated\u00a0that the pen diagnoses cancer in\u00a0live, tumor-bearing mice during\u00a0surgery without causing any observable\u00a0harm to the tissue or stress to\u00a0the animals.<\/p>\n

\u201cWe anticipate certain lesions\u00a0will be 90 to 95 percent probable\u00a0of a tissue diagnosis, but we want\u00a0to give a more precise diagnosis,\u201d\u00a0Suliburk said. \u201cOur goal is to be\u00a0more than 95 percent accurate.\u201d<\/p>\n

The team is now refining the\u00a0MasSpec Pen so it can read samples\u00a0placed on microscope slides.<\/p>\n

Suliburk expects to start testing\u00a0the MasSpec Pen during oncologic\u00a0surgeries this spring. The team\u00a0hopes the U.S. Food and Drug\u00a0Administration will approve the\u00a0pen as a medical diagnostic.<\/p>\n

\u201cDr. Eberlin and I both feel\u00a0strongly that it will improve the\u00a0care of the patient and revolutionize\u00a0how we perform surgery,\u201d Suliburk\u00a0said. \u201cAny time you can perform a\u00a0more precise, safer surgery, it\u2019s a\u00a0win for the patients and results in\u00a0better outcomes.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"

One telephone call triggered\u00a0a new device that aims\u00a0to give surgeons more precise\u00a0diagnostic information about\u00a0what to cut and what to preserve\u00a0during cancer surgery. Livia Schiavinato Eberlin, Ph.D.,\u00a0assistant professor of chemistry\u00a0at The University of Texas (UT) at\u00a0Austin, made that phone call, and\u00a0James Suliburk, M.D., associate\u00a0professor and head of endocrine surgery\u00a0at Baylor College of Medicine, answered it. \u201cShe […]<\/p>\n","protected":false},"author":21,"featured_media":11292,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[1],"tags":[6,2479,142],"yoast_head":"\nMasSpec Pen Aims to Detect Cancer in Real Time<\/title>\n<meta name=\"description\" content=\"One telephone call triggered a new medical device that aims to give surgeons more precise diagnostic information about what to cut and what to preserve during cancer surgery.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link 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