Chinnaswamy Jagannath, PhD: Improving Tuberculosis Vaccines Through Autophagy
Chinnaswamy Jagannath, PhD
Houston Methodist Research Institute
Vaccines have a major impact on public health and are crucial for improving overall health and prolonging life. However, for many infectious diseases, vaccines are either not yet available or have only short-term efficacy. Despite the BCG vaccine, tuberculosis kills millions of people each year. Dr. Jagannath and his team have discovered that inducing autophagy during vaccine antigen processing in macrophages and dendritic cells enhances vaccine efficacy and long-term protection. They are currently exploring how engineering autophagy during vaccines development induces the capability of live attenuated bacterial vaccines and attenuated viral mucosal vaccines to strengthen vaccine-induced protection.