Center for Theoretical Biological Physics Research Seminar
Nikolay V. Dokholyan
Department of Pharmacology and
Department of Biochemistry & Molecular Biology
Penn State College of Medicine
“Molecular Design for Research and Therapeutics”
Abstract: Life of biological molecules spans time and length scales relevant at atomic to cellular time and length scales. Hence, novel molecular modeling approaches are required to be inherently multi-scale. Here we describe multiple methodologies developed in our laboratory: rapid discrete molecular dynamics simulation algorithm, protein design and structural refinement tools. Using these methodologies, we describe therapeutic strategies to combat this HIV and cancer, as well as design novel approaches for controlling proteins in living cells and organisms.
Bio: Dr. Dokholyan received his Ph.D. in Physics at the Boston University under the supervision of Dr. H. Eugene Stanley in 1999. His work spanned the area of statistical mechanics and its applications to biological macromolecules. Upon graduation Dr. Dokholyan joined Dr. Eugene Shakhnovich at Harvard University Department of Chemistry and Chemical Biology as a NIH NRSA Fellow. His work was focused on protein folding, design, and evolution. He joined Department of Biochemistry and Biophysics in the University of North Carolina at Chapel Hill, School of Medicine as an Assistant Professor in 2002, promoted to an Associate Professor in 2008, and to Full Professor in 2011. Dr. Dokholyan is currently the Director of the Center for Computational and Systems Biology and the Graduate Director of the Program in Molecular and Cellular Biophysics at UNC. Dr. Dokholyan has published 180 per review articles and 16 book chapters. He was named American Physical Society Fellow in 2013. In 2014, he was named Michael Hooker Distinguished Professor. Over the past decade Dr. Dokholyan has been working in two principal directions: methodology development to understand and engineer molecular structure and function and application of these methodologies to understand the etiologies of human diseases and develop therapeutic strategies.