Mendelsohn was diagnosed with glioblastoma 15 months ago and succumbed to the aggressive brain cancer which also claimed the lives of U.S. Sen. John McCain, U.S. Sen. Ted Kennedy and Former Vice President Joe Biden’s son, Beau.
A memorial service is set for 11 a.m. Monday, Jan. 14, at the Lillie and Roy Cullen Theater at the Wortham Center in downtown Houston.
Mendelsohn, a professor of genomic medicine, was the third president of MD Anderson and inspired the cancer center’s “Making Cancer History” slogan. His 15 years of leadership spanned significant achievements in research and patient care. He “directed substantial growth in staff, programs, facilities and philanthropy,” according to an MD Anderson news release. During each of his last five years as president, MD Anderson was named the top cancer hospital in the annual “Best Hospitals” survey published by U.S. News & World Report.
“We’re so sad and, obviously, mourning as an institution, as is the entire cancer community and everyone who knew and loved John,” said MD Anderson President Peter WT Pisters. “He is considered a very powerful figure nationally and internally in the field of personalized cancer medicine. That’s the field where we really interrogate the tumor for specific mutations and then treat those mutations with specific, targeted drugs. It’s also a field where we consider the needs of the patient holistically and approach the patient as a person—not as a tumor.”
During Mendelsohn’s tenure, MD Anderson’s revenue increased from $726 million to $3.1 billion, and its facilities grew from 3.4 million square feet to 15.2 million square feet. The number of employees and patients doubled and private philanthropy increased nearly tenfold to more than $2 billion raised.
“He was an amazing man. He was very friendly and generous and open,” said Andrea White, a local writer and former first lady of Houston whose husband, Bill White, served as mayor from 2004 to 2010. “When I think of him, I think of his enormous smile. Despite being so scientific, he was just openly warm with so many people. I really attribute his gift of warmth to the fact that MD Anderson is credited with being such a warm place for patients to go. That was in his DNA and he got that DNA into the culture of MD Anderson.”
Mendelsohn was born in Cincinnati. In 1958, he graduated magna cum laude from Harvard College, where he earned his bachelor’s degree in biochemical sciences. While there, he was the first undergraduate student to work in the laboratory of a new assistant professor, biochemist James D. Watson, Ph.D., who later won the Nobel Prize in Medicine for identifying the structure of DNA.
He graduated cum laude from Harvard Medical School in 1963. From 1963 to 1970, he took residency training in internal medicine at Brigham and Women’s Hospital in Boston, and then completed a research fellowship at the National Institutes of Health and a fellowship in hematology-oncology at Washington University Medical School in St. Louis.
Mendelsohn joined the newly established UCSD School of Medicine faculty in 1970 and became the founding director of the University of California, San Diego’s cancer center. In the early 1980s, he began researching ways to fight cancer by blocking epidermal growth factor receptors. His work with Gordon Sato, Ph.D., and other UCSD colleagues that led to the development of the monoclonal antibody that later became Erbitux, also known as cetuximab. The drug was approved by the U.S. Food and Drug Administration in 2004 for treating advanced colorectal cancer and in 2006 for head and neck cancer.
Later, Mendelsohn served as chair of the Department of Medicine at Memorial Sloan Kettering Cancer Center in New York City, where he held the Winthrop Rockefeller Chair in Medical Oncology. He also was co-head of the Program in Molecular Pharmacology and Therapeutics, as well as professor and vice chair of medicine at Cornell Weill Medical College. In 1996, he left his posts in New York to become president of MD Anderson.
Pisters and his wife—Katherine Pisters, M.D., a medical oncologist at MD Anderson—knew Mendelsohn in New York City when they all worked at Sloan Kettering. The Pisters moved to Houston to work at MD Anderson in 1994, two years before Mendelsohn arrived.
“I had the incredible opportunity to observe him as president for all 15 years that he served the organization in the role that I am now privileged to be in. That was an unbelievable course in leadership,” Peter WT Pisters said. “I inherited an organization that really has benefited enormously from John’s work, efforts and vision.”
The cancer center was transformed during the Mendelsohn years. Campus migration within the TMC expanded MD Anderson’s footprint and set the stage to “regionalize” care across the Houston metro area.
“John put us on a pathway to move from a single point-of-service organization to an integrated delivery system across Houston,” Pisters said. “It was really a type of organizational metamorphosis and we are now at the point where the flower is appearing.”
Pisters also reflected on the MD Anderson community treating their president emeritus, who retired in August, as a patient.
“When we see colleagues migrate across the divide and they are now on the other side of the white coat, it is really profound,” he said. “And for our faculty members who had the privilege of caring for John, I know it was one of the most extraordinary privileges of their entire careers.”
Mendelsohn also made an impact on several Houston nonprofit organizations as well as to advance collaborative research between academia and industry. He chaired the board of directors of the Houston Grand Opera and served as vice chair of the board of BioHouston, Inc., a nonprofit corporation created in 2001 to promote the Houston area as a global competitor in life science and biotechnology commercialization.
“The other thing that should be emphasized is the commitment that John and his wife, Anne, had to Houston as a community. They set an amazing example for us as very strong and visible supporters of not only MD Anderson, but the entire Houston community including the Houston Symphony, Teach for America and many other non-medical-related community organizations,” Pisters said. “I know that John will be missed.”
In recognition of his many contributions, the John Mendelsohn Faculty Center was dedicated on Feb. 8, 2012.
Mendelsohn returned to MD Anderson in March 2012 to co-lead the Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy (IPCT) to advance personalized medicine. He also joined Rice University’s James A. Baker III Institute for Public Policy as the first L.E. and Virginia Simmons Senior Fellow in Health and Technology Policy that same year.
Mendelsohn “listened to people and he led effectively because of that,” White added. “He had the scientific gravitas and the people skills that allowed MD Anderson to flourish.”
He is survived by his wife, Anne, as well as their son Andrew and his wife, Tina, of London; son Eric and his wife, Isabel, of Summit, New Jersey; and son Jeffrey of San Francisco; and eight grandchildren.
Memorial contributions may be made to the Anne and John Mendelsohn Chair in Cancer Research at MD Anderson Cancer Center, P.O. Box 4486, Houston, TX 77210-4486 or www.mdanderson.org/gifts or the Houston Grand Opera, 510 Preston St., Houston, Texas 77002 or https://www.houstongrandopera.org/support-us/donation.
TMC Pulse Editor Maggie Galehouse contributed to this report.
WESTCHESTER COUNTY, NY: Operation To Help Young Military Veterans Adjust To Everyday Life https://t.co/OnFRQbh1UC via @CBSNewYork
#Immunotherapy has shown remarkable success, but it doesn’t work for everyone and results can vary.That’s why our researchers are conducting #clinicaltrials that combine immunotherapy with other therapies: https://t.co/klJw9jdvG8 #endcancer
@thadroher Thank you, Thad. We are grateful for your support.
Bikers honor Vets: ‘Run for the Wall’ stopping in Longview, TX https://t.co/miAB7a2A9b via @KLTV7
U.S. Department of Veterans AffairsVeteransAffairs
Today’s #VeteranOfTheDay is Marine Corps Veteran Brad Pesek. Brad served for 20 years and made multiple deployments during Operation Iraqi Freedom.Born in Saint Louis, Missouri, Brad enlisted with the United States Marine Corps in June 1998. He attended boot camp at the Marine Corps Recruit Depot in San Diego, California and infantry training at Camp Pendleton, California.After completing his training, Brad was assigned to Bravo Company, 1st Battalion, 3rd Marines stationed at Marine Corps Base Hawaii. There, Brad was deployed twice to Okinawa, Japan as part of the Unit Deployment Program.Following his time at Marine Corps Base Hawaii, Brad was assigned to the School of Infantry at Camp Pendleton, California. There, he served as a Marine combat instructor and reached the rank of sergeant.After his time serving as an instructor at Camp Pendleton, Brad was assigned to 3rd Battalion, 5th Marines, where he served as a squad leader, machine gun section leader, mortar section leader, and platoon sergeant. During his time with 3/5, Brad was deployed twice to Iraq in support of Operation Iraqi Freedom, once in January 2006 and once in September 2007.Following his time with 3/5, Brad returned to the School of Infantry at Camp Pendleton for a second tour as a Marine Combat Instructor. There, Brad was assigned to the Infantry Squad Leader Course, where he served as a squad instructor, assistant chief instructor, and later chief instructor. By December 2010, Brad had earned the rank of gunnery sergeant.Upon completing his tour as a Marine combat instructor, Brad was assigned to 2nd Battalion, 3rd Marines stationed at Marine Corps Base Hawaii. There, he served as a weapons platoon sergeant and company gunnery sergeant. During this time, Brad deployed twice in support of the Unit Deployment Program, serving in Darwin, Australia in 2012 for the first Marine Rotational Force-Darwin and in Okinawa, Japan in 2013.Following his time with 2/3, Brad began working as the assistant training chief for the 1st Marines, G-3 Training Section at Camp Pendleton, California. In January 2015, Brad was promoted to first sergeant and assigned as company first sergeant of the 1st Marine Raider Support Battalion.Brad retired from the Marine Corps in February 2019 after 20 years of service. Throughout his long service, Brad earned the Navy and Marine Corps Commendation Medal, the Navy and Marine Corps Achievement Medal with Combat Distinguishing Device, the Combat Action Ribbon, and the Meritorious Service Medal.Thank you for your service, Brad!
University of Houston@UHouston
RT @FrontierFiesta: 📸LIVE right now at #FrontierFiesta! https://t.co/PwwxUeSu3V
Today’s #VeteranOfTheDay is Marine Corps Veteran Brad Pesek. Brad served for 20 years and made multiple #OIF deployments https://t.co/JDJk73aIjb
University of Houston@UHouston
RT @MarchMadnessTV: Houston is on a mission to make the city proud.Kelvin Sampson has fostered a family atmosphere all around @UHCougarMB…
See how Melanie McNeal stays fit in this week's healthy habits post. https://t.co/YDURUq6Ii5 #healthy #habits
Baylor College of MedicineBaylorCollegeOfMedicine
For decades, the link between education and healthcare has been the driving concept behind development of programs to improve community health at Baylor College of Medicine. Learn more about our initiatives: https://bit.ly/2t4NynV #education #community
U.S. Department of Veterans AffairsVeteransAffairs
Happy Birthday, Frank!
Families with children of all abilities are invited to the annual Texas Children’s West Campus Family Fun Run on Saturday, April 6. Register your family at https://t.co/kj6xpuWTSJ
“People who carry hereditary mutations do not necessarily get cancer, but their risk of developing the disease at some point during their lifetime is higher than average,” says our @KarenLuMD.How we help those with genetic risk of #cancer: https://t.co/W6Rf3WPl9r #endcancer
MD Anderson Cancer CenterMDAnderson
"I was really worried about the recovery," recalls Bridgette Fleming, who underwent laparoscopic colon resection in late March 2018 to treat her colon cancer. "But I was surprised that even after a major abdominal surgery, I only had to use the pain pump twice a day for a few days."Here's how our Enhanced Recovery Program is helping patients like Bridgette rebound faster after surgery. #endcancer
A candlelight vigil was held March 20 commemorating the 50 lives lost in the New Zealand mosque attacks.On March 27, Rice will host an Islamophobia teach-in all day in solidarity with the Muslim community: https://t.co/ugA11IDcGz https://t.co/8siFEZshmc