Clinical Research

African American Prostate Cancer Study includes Baylor


By Christine Hall | August 8, 2018

Baylor College of Medicine is among a national network of health care institutions and collaboratives recruiting for what is described as the largest coordinated research study of aggressive prostate cancer in African American men.

An estimated 30,000 African American men were diagnosed with prostate cancer in 2016, according to the American Cancer Society’s most recent figures, and the disease is believed to have killed more than 4,400 black men that year. Black men are twice as likely to die from prostate cancer than white men and have the highest death rate from the disease among all racial or ethnic groups in the United States, findings show.

Research on Prostate Cancer in Men of African Ancestry: Defining the Roles of Genetics, Tumor Markers, and Social Stress—also known as RESPOND—is a $26.5-million, multi-institutional study funded by the National Cancer Institute, the National Institute on Minority Health and Health Disparities and the Prostate Cancer Foundation.

RESPOND will examine the impact of social stressors such as discrimination along with socioeconomic status, education, home life, residence location and early life events as well as genetic and biological factors in the development and progression of prostate cancer in African American men. The study also will explore why black men are at higher risk for developing more aggressive forms of the disease and why their mortality rate is higher.

Melissa Bondy, prostate cancer, Baylor College of Medicine
Melissa Bondy, Ph.D., professor of medicine – epidemiology and population sciences and associate director of cancer prevention and population sciences in the Dan L Duncan Comprehensive Cancer Center at Baylor College of Medicine

Leading the study for Baylor is Melissa Bondy, Ph.D., professor of medicine – epidemiology and population sciences and associate director of cancer prevention and population sciences in the Dan L Duncan Comprehensive Cancer Center.

“While looking at cases, Texas stood out,” she said. “Some 1,700 African American men are diagnosed in Texas annually.”

The study aims to recruit 10,000 African American men nationwide over the next five years. Each participant will be asked to provide a saliva sample and allow researchers to access his prostate cancer biopsy tissue. The samples will be analyzed to identify genetic markers of prostate cancer and unique tumor characteristics.

Recruiting this population may be a challenge, said Bondy, who has previously sought participants for breast cancer research. This will be her first time recruiting for prostate cancer.

She noted that men, in general, don’t like to participate in research, but said the prostate cancer researchers are getting creative in their approach by looking at recruitment through barbershops.

“We may have to rethink how to do this,” she said. “This is a hard group to reach. They are not used to participating in research and tend to be older men. They are also more curious about what we will do with the information.”

Bondy hopes to enroll about 3,000 study participants from Texas with a process that will kick off with focus groups this summer. Recruitment begins in January.

The Keck School of Medicine at the University of Southern California will lead the study. Other participating institutions include Rutgers Cancer Institute of New Jersey with the New Jersey Department of Health, Public Health Institute with the Cancer Registry of Greater California, Emory University, Dana-Farber Cancer Institute with Harvard University, Johns Hopkins University, Louisiana State University Health New Orleans, Moffitt Cancer Center, Barbara Ann Karmanos Cancer Institute with Wayne State University and the University of California, San Francisco.




Social Posts

profile_image

Harris Health System

@harrishealth

RT @HoustonFoodBank: Houston Food Bank got to attend the Healthier Texas Summit by @ItsTimeTX along with our partners in implementing a Foo…

10 mins ago
profile_image

Memorial Hermann

@memorialhermann

Today we are celebrating a special four-legged employee’s birthday. Learn more about Dexter’s job as Children's Memorial Hermann Hospital’s facility dog: https://t.co/8JWEJ14YdE. #dog #hospital https://t.co/L5mCMsNezE

10 mins ago
profile_image

Veterans Affairs

@DeptVetAffairs

State Dept. VIP fellowship opens application period https://t.co/FbRosem1Ti via #VAntagePoint

18 mins ago
profile_image

MD Anderson Cancer Center

@MDAndersonNews

@KrissKringle Stella and her family are in our prayers.

25 mins ago
profile_image

BCMHouston

@bcmhouston

Dr. Prathap Jayaram is joined by a special guest to show why it is important for scientists and researchers to talk with others about their work. View the full video on our Facebook page. #BCMAskMeAboutMyResearch https://t.co/KNTa3kangR

48 mins ago
profile_image

Veterans Affairs

@DeptVetAffairs

RT @VAResearch: #VAResearchNewsBrief Supported employment improves overall #PTSD-related functioning, found a @DeptVetAffairs study. Indivi…

50 mins ago
profile_image

BCMHouston

@bcmhouston

RT @BCMHoustonJobs: Interested in a job in #Houston, TX? This could be a great fit: https://t.co/n8VDnCEbGz #Healthcare

55 mins ago
profile_image

Memorial Hermann

@memorialhermann

Rusti is celebrating two milestones this month—turning 75 and being cancer-free. Read her story: https://t.co/wFp5OCWzbK. #cancerfree #breastcancerawareness

60 mins ago
profile_image

BCMHouston

@bcmhouston

RT @ChronMed: Hurricane Harvey increased risk of serious medical complications in both pregnant women and their newborn babies, finds @bcmh…

1 hour ago
profile_image

UTMB Health

@utmbhealth

RT @UTMBProvost: SGA President Faith Mason, class of 2020, accepts the Health Education Center on behalf of the student body. She says inte…

2 hours ago
profile_image

UTMB Health

@utmbhealth

RT @UTMBProvost: Janiece Longoria, Vice Chair, @utsystem Board of Regents, dedicates the Health Education Center, stating its importance to…

2 hours ago
profile_image

MD Anderson Cancer Center

@MDAndersonNews

.@pedroramirezMD shares how our multidisciplinary approach offers gynecologic cancer patients more options: https://t.co/WvLT8kZ2yW #gyncsm #endcancer https://t.co/k5n5Z8kwJI

2 hours ago
profile_image

Texas Children's

@TexasChildrens

The Department of Surgery at @TexasChildrens offers same-day surgical consultation appointments when you call to make an appointment before 12 pm. Learn more: https://t.co/3eTrQv6DeW https://t.co/M50f2eVpds

2 hours ago
profile_image

UTMB Health

@utmbhealth

RT @UTMBProvost: Dr. John Zerwas, Executive Vice Chancellor for Health Affairs, @utsystem, says, “UTMB has led so many innovations in healt…

2 hours ago
profile_image

CHI St. Luke's Health

@CHI_StLukes

Can excess weight damage DNA to the point of tumor growth? The link between obesity and liver cancer may be more direct than previously thought: https://t.co/PYzOZS0caO @SeragHashem #LCAM2019 https://t.co/tFfmfmqjNT

2 hours ago