Research

Solutions: Eating for Life

Spermidine, a food compound, may help prevent disease and prolong life


By Christine Hall | November 1, 2017

Which foods help us live longer? Texas Medical Center researchers aim to prove that spermidine-rich foods help prevent disease and increase the lifespan of humans.

Spermidine, a type of organic compound called a polyamine, was first isolated from semen, hence its name.

The compound is found in aged cheese, mushrooms, soy products, legumes, yogurt with probiotic LKM512, deepsea snails, corn and whole grains.

Leyuan Liu, Ph.D., assistant professor at the Center for Translational Cancer Research at Texas A&M Institute of Biosciences and Technology, is part of a group that has found spermidine to prevent liver fibrosis and hepatocellular carcinoma (HCC), a common type of liver cancer, in animal models.

In addition, Liu’s research group sees evidence that the compound may prolong life. The group’s research, published in the June 2017 edition of Cancer Research journal, shows that spermidine works to prevent cancer by activating MAP1S-mediated autophagy, or the natural self-destroying behavior of cells. When MAP1S isn’t available, the benefits of spermidine disappear, Liu said.

Liu has studied autophagy in earlier work and found that cells accumulating waste caused by defective autophagy can go on to replicate and become tumors or cause other problems.

“The autophagy essentially works like a cleaning system for the body,” Liu said. Spermidine can prevent the defective autophagy process, and may even improve cardiovascular health.

An abstract from the Cancer Research article notes: “Extending recent evidence that orally administered spermidine can extend lifespan in mice, we determined that life extension of up to 25 percent can be produced by lifelong administration, which also reduced liver fibrosis and HCC focias induced by chemical insults. … Our findings offer a preclinical proof of concept for the administration of oral spermidine to prevent liver fibrosis and hepatocellular carcinomas and potentially extend lifespan.”

The researchers tested their hypothesis by giving mice an oral supplement of spermidine in their drinking water.

They found the mice lived longer and were less likely than untreated mice to have liver fibrosis and cancerous liver tumors, even if the treated mice were predisposed for those illnesses.

People who hope to get the most benefit from spermidine would need to eat spermidine-rich foods from the time they begin to eat solid foods, Liu said.

At the moment, there are three ways to help combat liver fibrosis and hepatocellular carcinoma: fasting, restricting the amount of methionine (a type of amino acid found in meat and other proteins) in your diet, or taking a drug called rapamycin, Liu said.

“Eating less, or not eating meat, is not a popular option for the general population to accept, so spermidine which they could get from products like aging cheese and soy beans, could become a new way,” he said.

Even people who aren’t able to take spermidine until later in life should see some benefits, Liu said. The animal models involved in the study who were exposed to spermidine showed reductions in both liver lesions and intensity of liver fibrosis, a condition that often leads to liver cancer.

Liu hopes to incorporate spermidine into foods in much the same way folic acid has been added to grain products, like beer.

The next step for the research group is to determine how much spermidine is needed to help humans, and how to deliver a long-term supplement that will be safe. Liu is optimistic this can happen, and the group is currently exploring National Institutes of Health grants to support their efforts.




Social Posts

profile_image

University of Houston

@UHouston

RT @FrontierFiesta: 📸LIVE right now at #FrontierFiesta! https://t.co/PwwxUeSu3V

32 mins ago
profile_image

Veterans Affairs

@DeptVetAffairs

Today’s #VeteranOfTheDay is Marine Corps Veteran Brad Pesek. Brad served for 20 years and made multiple #OIF deployments https://t.co/JDJk73aIjb

48 mins ago
profile_image

University of Houston

@UHouston

RT @MarchMadnessTV: Houston is on a mission to make the city proud.Kelvin Sampson has fostered a family atmosphere all around @UHCougarMB…

2 hours ago
profile_image

BCMHouston

@bcmhouston

See how Melanie McNeal stays fit in this week's healthy habits post. https://t.co/YDURUq6Ii5 #healthy #habits

2 hours ago
profile_image

Baylor College of Medicine

BaylorCollegeOfMedicine

For decades, the link between education and healthcare has been the driving concept behind development of programs to improve community health at Baylor College of Medicine. Learn more about our initiatives: https://bit.ly/2t4NynV #education #community

2 hours ago
profile_image

Veterans Affairs

@DeptVetAffairs

SECCA Presents Staged Reading of WWII Pacific Engagement Veterans’ Stories https://t.co/rFBKFyDPpc via @yesweekly

3 hours ago
profile_image

U.S. Department of Veterans Affairs

VeteransAffairs

Happy Birthday, Frank!

3 hours ago
profile_image

Texas Children's

@TexasChildrens

Families with children of all abilities are invited to the annual Texas Children’s West Campus Family Fun Run on Saturday, April 6. Register your family at https://t.co/kj6xpuWTSJ

3 hours ago
profile_image

MD Anderson Cancer Center

@MDAndersonNews

“People who carry hereditary mutations do not necessarily get cancer, but their risk of developing the disease at some point during their lifetime is higher than average,” says our @KarenLuMD.How we help those with genetic risk of #cancer: https://t.co/W6Rf3WPl9r #endcancer

3 hours ago
profile_image

MD Anderson Cancer Center

MDAnderson

"I was really worried about the recovery," recalls Bridgette Fleming, who underwent laparoscopic colon resection in late March 2018 to treat her colon cancer. "But I was surprised that even after a major abdominal surgery, I only had to use the pain pump twice a day for a few days."Here's how our Enhanced Recovery Program is helping patients like Bridgette rebound faster after surgery. #endcancer

3 hours ago
profile_image

MD Anderson Cancer Center

@MDAndersonNews

Congratulations on another great event, @CathyEngMD, and thanks for all you do to help us #endcancer. https://t.co/tzg8ukTJuL

3 hours ago
profile_image

MD Anderson Cancer Center

@MDAndersonNews

RT @wendyegriffith: #AYACancer Scholarship Program is open for @MDAndersonNews & @KidsAndCancer patients aged 16-29 seeking post-high schoo…

4 hours ago
profile_image

Rice University

@RiceUniversity

A candlelight vigil was held March 20 commemorating the 50 lives lost in the New Zealand mosque attacks.On March 27, Rice will host an Islamophobia teach-in all day in solidarity with the Muslim community: https://t.co/ugA11IDcGz https://t.co/8siFEZshmc

4 hours ago
profile_image

Veterans Affairs

@DeptVetAffairs

Inside Oneida County's fight to end Veteran homelessness https://t.co/0QosaHZPhl via @uticaOD

5 hours ago
profile_image

BCMHouston

@bcmhouston

For decades, the link between education and healthcare has been the driving concept behind development of programs to improve community health at Baylor College of Medicine. Learn more about our initiatives: https://t.co/wtLRXl71w6 #education #community https://t.co/kyJoF4rIye

6 hours ago