Signaling in Cell Shape & Motility: from Single Cells to the Collective Behavior of Multiple Cells
The Center for Theoretical Biological Physics PRESENTS Seminar Speaker Dr. Leah Edelstein-Keshet Professor Department of Mathematics University of British Columbia Abstract: In this talk I will describe recent work on the signaling inside cells that controls the cytoskeleton, and thereby the shape and motility of a eukaryotic cell. I will focus on our recent analysis of regulatory proteins (the small GTPases Ran and Rho, known to be mutually antagonistic), and how their interactions can account for cell spreading, contraction, and polarization. An application to the experimentally observed dynamics of melanoma cells will be highlighted. I will also describe some of our recent work spanning the single and multiple cell levels. An example of the subdivision of a developing tissue (lateral line primordial) in the zebrafish embryo will be described.
BioScience Research Collaborative, Room 1060 A/B
6500 Main St.