Mikhail G. Kolonin, Ph.D.: Obesity and Cancer Treatment by Targeting Adipocyte Progenitors
Mikhail G. Kolonin, Ph.D.
Harry E. Bovay, Jr. Distinguished University Chair in Metabolic Disease Research
Director, Center for Metabolic and Degenerative Diseases
The University of Texas Health Science Center at Houston
Relative abundance of thermogenic beige adipocytes and lipid-storing white adipocytes in adipose tissue underlie the progression of obesity and metabolic disease. Dr. Kolonin will discuss developing ‘hunter-killer’ peptides for targeted ablation of cells in adipose tissue. D-WAT, targeting white adipocyte progenitors, suppresses obesity development and enables maintenance of active metabolism. It also suppresses tumor growth and synergizes with cancer chemotherapy by disabling adipose stromal cell contribution to tumor microenvironment. Adipotide, targeting endothelial cells and adipocytes in white fat, reverses obesity. Finally, he has developed a hunter-killer compound D-BAT, based on a peptide that targets brown fat tissue, which may relieve hypermetabolic conditions.
For abstract and location information: events.houstonmethodist.org/mikhail-kolonin
Houston Methodist Research Institute
6670 Bertner Avenue
Houston, Texas 77030
Houston Methodist Events