Matthew D. Cykowski, M.D.: Misfolded TAR DNA-binding Protein 43 (TDP-43) in Amyotrophic Lateral Sclerosis: Clinical Significance of a Potential Diagnostic Biomarker

Wednesday, October 4, 2017 | 1:00 PM - 2:00 PM Add to Calendar

Houston Methodist Research Institute presents:
Matthew D. Cykowski, MD
Staff Pathologist
Department of Pathology and Genomic Medicine
Houston Methodist

Amyotrophic lateral sclerosis (ALS) is a progressive neurological disease characterized by upper and lower motor neuron signs and symptoms, as well as muscle weakness and atrophy. These symptoms reflect degeneration across the entire motor system (i.e. motor neuron groups, axons, neuromuscular junction). Both cell-autonomous and non-cell-autonomous mechanisms of injury have been demonstrated in patients and in animal models of ALS. This presentation will focus on:

  • Recent clinical and pathological studies of cell autonomous forms of neuronal and myocyte injury in ALS
  • How these studies relate to clinical findings
  • How these studies may further inform our understanding of disease pathogenesis and progression

For more information and registration, visit:


Houston Methodist Research Institute

6670 Bertner Ave.
Boardroom R2-311
Houston, Texas 77030


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