DNA Programmed Dynamical Systems Outside Cells: from Gene Circuits to Self-Assembly
The Center for Theoretical Biological Physics PRESENTS Seminar Speaker Dr. Vincent Noireaux Associate Professor School of Physics and Astronomy University of Minnesota TUESDAY, JANUARY 31, 2017 12:30 – 1:30 PM BRC, 10TH FLOOR, ROOM 1060 A/B Abstract: The analysis and characterization of complex dynamical interactions involved in gene regulation is a major theme in post-genomic research. Researchers from many different backgrounds have developed novel approaches to dissect gene network and to determine their basic principles. In this talk I will present a unique cell-free platform that my lab has developed to construct complex information-based dynamical systems by executing gene circuits in vitro. Our first goal was to prototype and to understand elementary regulatory gene networks in test tube reactions. Recently, we showed that our experimental platform is capable of recapitulating larger biochemical systems such as the complete synthesis of viruses that we use as a model of information to self-assembly process. Finally, I will show how we can execute gene circuits in synthetic liposomes to emulate biological functions in a synthetic cell analog. Bio: Vincent Noireaux attended graduate school at the University Paris 11 (Orsay), in biological physics. He did his PhD at the Curie Institute (Paris, 1996-2000) in the laboratory of Jacques Prost. He studied the actin cytoskeleton mechanism involved in cell motility in collaboration with the laboratory of Daniel Louvard. In 2000 he joined the laboratory of Albert Libchaber at the Rockefeller University in New York City where he spent five years as a postdoc. He used cell-free expression to construct elementary gene networks and to develop a minimal cell system. In 2005, he moved to the University of Minnesota where he is pursuing his work in synthetic biology using cell-free expression to construct and to study biochemical systems in vitro.
BioScience Research Collaborative, Room 1060 A/B
6500 Main St.