Regenerative Medicine

Deconstruction of Corticospinal Circuits to Repair Damaged Corticospinal System

Wednesday, November 15, 2017 | Noon - 1 pm Add to Calendar

Houston Methodist Center for Neuroregeneration presents:

Xuhua Wang, PhD
Postdoctoral Research Fellow
Department of Neurobiology
F.M. Kirby Neurobiology Center
Boston Children’s Hospital
Harvard Medical School

“Deconstruction of Corticospinal Circuits to Repair Damaged Corticospinal System”

Corticospinal neurons (CSNs) represent the direct cortical outputs to the spinal cord and play important roles in motor control. However, their organizational principle remains unclear. Retrograde labeling enabled the definition of CSN requirements in the execution of a skilled task in mice. In vivo imaging of CSN activity revealed the sequential activation of topographically ordered functional ensembles with moderate local mixing. Region-specific manipulations indicate that CSNs from caudal or rostral forelimb area control reaching or grasping, respectively, and both are required in the transitional pronation step. Overall, these findings suggest that spatially defined groups of CSNs encode different movement modules, providing a logic for parallel-ordered corticospinal circuits to orchestrate multistep motor skills.

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