Cardiology

“The Contraction of Space and Time in Genomic Interactions”


Tuesday, September 26, 2017 | 12:30 - 1:30 PM Add to Calendar

The Center for Theoretical Biological Physics PRESENTS Seminar Speaker:
Olga Dudko
Professor
Department of Physics
University of California, San Diego

“The Contraction of Space and Time in Genomic Interactions”

Tuesday, September 26, 2017
12:30 – 1:30 PM
BRC, 10th Floor, Room 1060 A/B

Abstract:
Many processes in biology, from antibody production to tissue differentiation, share a common fundamental step — establishing physical contact between distant genomic segments. How fast this step is accomplished sets the “speed limit” for the larger-scale processes this step enables. A key outstanding question is then: How do genomic segments that are strung out over millions of base pairs along the DNA find each other in the crowded cell on a remarkably short timescale? This question, fundamental to biology, can be recognized as the physics problem of the first-passage time, or the waiting time for the first encounter. I will discuss how ideas from theoretical physics help reveal the physical principles by which cells solve this first-passage problem with astonishing efficiency. I will illustrate these ideas in the context of V(D)J recombination – the genetic mechanism that allows the human immune system to respond to millions of different antigens.

Bio:
Olga Dudko is a professor in the department of Physics at the University of California San Diego.

For more information and registration, visit: https://events.rice.edu/#!view/event/event_id/1025


Location

BioScience Research Collaborative (BRC)

10th Floor, Room 1060 A/B
6500 Main St, Houston, TX 77030

Contact

Lisa Bennett

713-348-8121