Communication Shapes Collective Information Encoding of Chemosensing
The Center for Theoretical Biological Physics
Department of Physics
Oregon State University
“Communication Shapes Collective Information
Encoding of Chemosensing”
Tuesday, September 19, 2017
12:30 – 1:30 PM
BRC, 10th Floor, Room 1060 A/B
Cells routinely sense and respond to their environment, and they also communicate with each other. Exactly how communication impacts sensing remains poorly understood. We study a population of fibroblast cells that responds to a chemical stimulus (ATP) and communicates by molecule exchange. Combining experiments and mathematical modeling, we find that cells exhibit calcium oscillations in response to not only the ATP stimulus but also, increased cell–cell communication. Our results show that, when cells are together, their sensory responses reflect not just the stimulus level but also, the degree of communication within the population.
Bo Sun received his B. S. degree in Applied Physics at Tsinghua University. Afterwards, obtained his Ph. D. degree in Physics at New York University in the laboratory of David Grier. During that time he worked on Holographic Optical Tweezers, Holographic 3D Microscopy, and stochastic colloidal dynamics. He graduated in 2010 and started to work as a postdoc associate with Howard Stone and Robert Austin at Princeton University on the physics of cancer. He is now an assistant professor at Oregon State University.
An Official Seminar of the Ph.D. Program in Systems, Synthetic and Physical Biology at Rice University
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BioScience Research Collaborative (BRC), 10th Floor, Room 1060 A/B
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