Given the ever-increasing obesity epidemic, researchers from The University of Texas Medical Branch at Galveston have discovered a promising developing drug that has been shown to selectively shrink excess fat by increasing fat cell metabolism. The drug significantly reduces body weight and blood cholesterol levels without lowering food intake in obese mice, according to a recent study published in Biochemical Pharmacology.
Obesity is a major public health problem around that world that is a leading cause of healthcare costs and compromised quality of life. In the U.S., 40 percent of adults are obese and 30 percent are overweight, battling serious obesity-related chronic diseases. The estimated cost of obesity in the U.S. is about $150 billion each year.
“As fat cells grow larger, they begin to overexpress a protein that acts as a metabolic brake that slows down fat cell metabolism, making it harder for these cells to burn accumulating fat,” said senior author Stanley Watowich, UTMB associate professor in the department of biochemistry and molecular biology. “In addition, as the fat tissue expands, they secrete greater amounts of hormones and pro-inflammatory signals that are responsible for several chronic diseases, including type 2 diabetes and cardiovascular disease.”
The researchers discovered a molecule that blocks this metabolic brake from operating in obese white fat cells. By blocking this metabolic brake, they were able to increase the metabolism within white fat cells.
In the study, mice were fed a high-fat diet until they became obese and then received either the drug or a placebo. Following 10 days of drug treatment, researchers found that the obese mice receiving the actual drug lost more than seven percent of their total body weight and their white fat tissue mass and cell size decreased by 30 percent compared with the placebo group. In addition, blood cholesterol in drug-treated mice were lowered to normal levels, similar to those of non-obese mice.
On the contrary, placebo-treated mice continued to accumulate white fat and gain weight throughout the study. Interestingly, mice in both the drug-treated and placebo groups consumed the same amount of food during the course of the study period, showing that the fat loss was not due to appetite suppression.
“Blocking the action of the fat cell brake provides an innovative ‘fat’-specific mechanism to increase cell metabolism and reduce the size of white fat deposits, thereby treating a root cause of obesity and related metabolic diseases,” said senior author Harshini Neelakantan, a UTMB research scientist in the department of biochemistry and molecular biology. “These initial results are encouraging and support further development of this technology as a new and more effective approach to combating metabolic diseases.”
Other study authors include UTMB’s Virginia Vance, Michael Wetzel, Celeste Finnerty and Jonathan Hommel as well as Hua-Yu Leo Wang and Stanton McHardy from the University of Texas at San Antonio.
At the Vietnam Memorial, a Lake Geneva Veteran bumps into a fellow Vet he hasn't seen in 48 years https://t.co/g1Cj0rXus9 via @620wtmj
U.S. Department of Veterans AffairsVeteransAffairs
The jumps were intended to raise awareness of Operation Enduring Warrior, a veteran-founded nonprofit organization with programs to aid wounded military and law enforcement veterans with physical and emotional rehabilitation.
“This study is proof of principle that we should keep going,” says our @JenniferLitton. #immunotherapy #bcsm #endcancer https://t.co/zUbvJvOqQF
RT @UHCougarFB: 📸 | The #HTownTakeover has arrived at Navy-Marine Corps Memorial Stadium. https://t.co/difmnpTYgt
Holocaust survivors visit museum with World War II Veterans https://t.co/JJOCvMt4U6 via @ABC7News
Learn how an #immunotherapy clinical trial gave #melanoma survivor Karlee Steele a chance to help other patients. #endcancer https://t.co/6OCovaOl5N
A revolutionary treatment for allergies to peanuts and other foods is going mainstream—but do the benefits outweigh the risks? Learn more via @sciencemagazine: https://t.co/NopMMWUDha #texaschildrens
Congratulations to the Dr. David Persse on receiving the American College of Emergency Physician's 2018 Outstanding Contribution to EMS award. https://t.co/olQqIQpndd
RT @UHpres: It needed a little editing! https://t.co/EC9HxN05NZ
West Virginia - More space to help counsel combat Veterans https://t.co/qPgeOFv4m5 via @WVVA
CHI St. Luke's Health@CHI_StLukes
Join us for our FREE event featuring multiple #childbirth and newborn education classes, door prizes, and a #HospitalTour. Get your tickets today: https://t.co/b8skGCLUG6 https://t.co/njd8HFqHxn
RT @UHCougarFB: ICYMI: Here's what we're wearing...⚪ Helmet ⚪ Jersey 🔴 Pants#HTownTakeover https://t.co/ONWITFNeLT
Curious about cochlear implants? Join the Center for Hearing and Balance for the 3rd annual Cochlear Implant Recipient and Candidate event on Oct. 23. https://t.co/B8n6K2BsnI
TAMU Health Sciences@TAMHSC
Rural Pharmacies Are Closing: Where Does That Leave Patients? | Patient Advice | US News https://t.co/HWf3bSegta@usnews @tamhsc_cop @rchitexas #RuralHealth #Pharmacist #Pharmacy #HealthCare #TAMHSC #AggieHealth #TAMUHealth #PatientCare https://t.co/PEDTarbxA9
#Cancer can be stressful. Find out how other survivors coped with stress and anxiety during treatment: https://t.co/WJb8aWh5z4 #endcancer https://t.co/F1sHd2NZbH