Events

Spatio-temporal Model for Silencing of Mitotic Spindle Assembly Checkpoints


By Texas Medical Center | January 28, 2015

Dr. Jian Liu
Investigator
Theoretical Cellular Physics
National Institutes of Health

Abstract: The spindle assembly checkpoint arrests mitotic progression until each kinetochore secures a stable attachment to the spindle. Despite fluctuating noise, this checkpoint remains robust and remarkably sensitive to even a single unattached kinetochore among many attached kinetochores; moreover, the checkpoint is silenced only after the final kinetochore-spindle attachment. Experimental observations have shown that checkpoint components stream from attached kinetochores along microtubules towards spindle poles. Here we incorporate this streaming behavior into a theoretical model that accounts for the robustness of checkpoint silencing. Poleward streams are integrated at spindle poles, but are diverted by any unattached kinetochore; consequently, accumulation of checkpoint components at spindle poles increases markedly only when every kinetochore is properly attached. This step change robustly triggers checkpoint silencing after, and only after, the final kinetochore-spindle attachment. Our model offers a conceptual framework that highlights the role of spatio-temporal regulation in mitotic spindle checkpoint signaling and fidelity of chromosome segregation.

Bio: Jian Liu graduated from Peking University with a B.S. in chemistry in 2000 and earned his Ph.D. in theoretical chemistry from the University of California, Berkeley in 2005. He completed postdoctoral fellowships at the University of California, San Diego, Center for Theoretical Biological Physics from 2005 to 2007 and at the University of California, Berkeley, Department of Molecular and Cell Biology in the laboratory of George Oster from 2007 to 2009. Dr. Liu joined the NHLBI as a tenure-track Investigator in 2009. Dr. Liu serves as a reviewer for the Journal of Chemical Physics, the Journal of Physical Chemistry, the Biophysical Journal, and Proceedings of the National Academy of Sciences.




Social Posts

profile_image

Veterans Affairs

@DeptVetAffairs

Vietnam veterans honored in pinning ceremony in Columbia https://t.co/hcsh0vLwyq via @fox43

7 hours ago
profile_image

MD Anderson Cancer Center

@MDAndersonNews

“I have a whole lot to be thankful for,” says Keith Taggart. Read how a Phase I #clinicaltrial helped him when he faced salivary gland cancer: https://t.co/RzkTa1MzPo @DrNeilGross @DavidHongMD #hncsm #endcancer

9 hours ago
profile_image

Veterans Affairs

@DeptVetAffairs

Paralyzed Marine pays it forward and stays ‘Oscar Mike’ https://t.co/u3hXC7ufCD via #VAntagePoint

9 hours ago
profile_image

MD Anderson Cancer Center

@MDAndersonNews

Combining immune checkpoint therapy with cytoreductive therapy may help patients with metastatic renal cell carcinoma, according to Phase I study by our team: https://t.co/gHHZM7PY3X @CancerTherAdvsr #kcsm #endcancer

9 hours ago
profile_image

UTHealth

@UTHealth

Bentley J. Bobrow, MD, who has focused his career on improving outcomes for emergency public health initiatives aimed at saving thousands of lives, has joined UTHealth as chair of the Department of Emergency Medicine at McGovern Medical School. https://t.co/Ftif8t3sHl https://t.co/j9FRyPimga

9 hours ago
profile_image

BCMHouston

@bcmhouston

Mouse lemurs could be the next model for genetics research. https://t.co/s2K8txwVCb #genetics

9 hours ago
profile_image

Texas Children's

@TexasChildrens

Texas Children's Pavilion for Women recently earned level IV maternal care designation. A level IV maternal care facility provides comprehensive care for pregnant and postpartum patients and more. Learn more from Houston Chronicle: https://t.co/mxxTc5Amqc

11 hours ago
profile_image

Veterans Affairs

@DeptVetAffairs

Combat Veteran roommates share stories, healing experience at VA North Texas https://t.co/f6m1e71PCp via #VAntagePoint

11 hours ago
profile_image

UTHealth

@UTHealth

RT @UTHpromotion: Welcome @UTHealth CPRIT Summer Undergraduate Fellowship led by Patricia Mullen, DrPH. The innovative #CancerPrevention re…

11 hours ago
profile_image

UTHealth

@UTHealth

RT @jvalenza: Wow, time really flies! Celebrating 5 years for the @UTHealth @UTSDhouston partnership with @TheCenterForCW, serving needy ch…

11 hours ago
profile_image

Houston Methodist

@MethodistHosp

@txumc @Forbes Thank you for the kind shout-out

12 hours ago
profile_image

TAMU Health Sciences

@TAMHSC

RT @AmerMedicalAssn: "I’d like to recognize two others who broke barriers in our organization. Dr. Lonnie Bristow, the first African Americ…

12 hours ago
profile_image

MD Anderson Cancer Center

@MDAndersonNews

A Phase I clinical trial by our researchers found using an investigational drug may disrupt the metabolic process some tumors rely on for growth and survival. #endcancer https://t.co/NAj0ulrPeA

12 hours ago
profile_image

Texas Children's

@TexasChildrens

This week, @TexasChildrens and The Woodlands Family YMCA are hosting a free Community Splash Day event focusing on water safety for kids. Learn more via @WoodlandsOnline: https://t.co/z6zLDG4CcN https://t.co/zkrZ1x5QLd

12 hours ago
profile_image

University of Houston

@UHouston

RT @uhparking: The Elgin Street under pass at Spur 5 has been closed by the @HoustonTX due to flooding. The remote campus shuttles have bee…

13 hours ago