The Center for Theoretical Biological Physics
Dr. Alan S. Perelson
Theoretical Biology & Biophysics Group
Los Alamos National Laboratory
“Mathematical Modeling and the Potential Cure of HIV”
Tuesday, January 13, 2015
12:30 – 1:30 p.m.
BRC, 10th Floor, Room 1060 A/B
Feel free to bring your lunch – A light lunch is provided for attendees at 12:15 p.m.
Abstract: Mathematical modeling has been a key part of HIV research since the mid-1990s. I will review some of the important insights gained through modeling so as to set the stage for understanding where the field is now and how it is approaching the possibility of curing HIV. I will present unpublished models that provide insight into a new phenomenon called post-treatment control of HIV in which some patients treated with antiviral therapy have been taken off of therapy and then spontaneously control HIV infection such that the amount of virus in the circulation is maintained undetectable by clinical assays for years. I will also discuss one of the hurdles to true HIV eradication, latently infected cells, and present clinical trial data and a new model addressing pharmacological means of flushing out the latent reservoir.
Bio: Alan S. Perelson has B.S. degrees in Life Sciences and in Electrical Engineering from MIT, and a Ph.D. in Biophysics from UC Berkeley. He has been an Acting Assistant Professor of Medical Physics at UC Berkeley, an Assistant Professor of Medicine at Brown University, and Group Leader of the Theoretical Biology and Biophysics Group at Los Alamos National Laboratory (LANL). He is now a Senior Fellow at LANL, an external professor at the Santa Fe Institute, and adjunct professor of Bioinformatics at Boston University, an adjunct professor of Biology at the University of New Mexico, and an adjunct professor of Biostatistics at the University of Rochester School of Medicine. He is a member of the American Academy of Arts and Sciences and the recipient of an NIH MERIT Award. He has published over 500 articles that have been cited over 45,000 times. His research focuses on developing models of the immune system and infectious diseases, such as HIV, HCV and influenza.
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